Prof. RNDr. Jiří Fajkus, CSc.

Basic CV Supervisor Qualifications Publications Projects Teaching

Person's identification

RNDr. Jiri Fajkus, CSc.
Born: 8 May 1964 in Brno, married, 2 children

Workplace

Masaryk University Brno
Faculty of Science
Department of Functional Genomics and Proteomics

Employment Position

Head of Department

Education and Academic Qualifications

1992: Ph.D. in Biophysics, Institute of Biophysics, Czech Acad. Sci.
1987: Master degree in Biochemistry, RNDr. title, Masaryk University Brno (J.E. Purkynije University)

Employment Summary

1998-2001: Masaryk University Brno
1988-2001: Institute of Biophysics, Czech Acad. Sci.
1987: J.E. Purkinje University (Masaryk University)

Pedagogical Activities

Structure and function of eukaryotic chromosomes (B9041) Seminar of the Department FGP (B9920) Diploma students of Mol. Biol. Genet. and biochemistry Ph.D. students of Mol. Cell. Biol. Member of the Board of postgraduate studies in Molecular and Cellular Biology.

Scientific and Research Activities

DNA conformation and chromatin structure of repetitive sequences, DNA methylation and its impact on chromatin structure, mapping of attachment sites of chromatin loops to nuclear matrix, analysis of telomere and subtelomere structure, detection of plant telomerase and studies on its developmental regulation and tissue specificity. Using telomere and telomerase analysis in oncology diagnostics. Inhibition of plant telomerase by telomere-binding proteins.

Academical Stays

1992: ICGEB UNIDO Centre Trieste, Italy
1992-1993, 1995 - Laval University Cancer Research Centre, Québec, Canada;
1996, 1998, 2000 - Weizmann Institute of Science, Dept. Structural Biology, Rehovot, Israel
1999 - Institute of Molecular and Cellular Biosciences, The University of Tokyo, Japan
2001 - Queen Mary and Westfield College, University of London, UK

University Activities

Member of the Board of postgraduate studies in Molecular and Cellular Biology
Member of the Board of the Biology Section Member of the Commitee for Selection proceedings

Extrauniversity Activities

member of the American Society for Microbiology member of the Genetic Society of J.G. Mendel scientific advisor of the American Society for Healthy Aging

Appreciation of Science Community

Prize of the Rector of the Masaryk (J. E. Purkinje) University and J. E. Purkinje Medal - 1987
Award of the Czech Ministry of Education "Talent 98" - 1999
Prize of the Minister of Education for Research - 2000.

Selected Publications

PROCHÁZKOVÁ SCHRUMPFOVÁ, Petra a Miloslava FOJTOVÁ a Petr MOKROŠ a Klaus D. GRASSER a Jiří FAJKUS. Role of HMGB Proteins in Chromatin Dynamics and Telomere Maintenance in Arabidopsis thaliana. CURRENT PROTEIN & PEPTIDE SCIENCE, BENTHAM SCIENCE PUBL LTD, 12, 2, od s. 105-111, 7 s. ISSN 1389-2037. 2011. info
PEŠKA, Vratislav a Petra PROCHÁZKOVÁ SCHRUMPFOVÁ a Jiří FAJKUS. Using the Telobox to Search for Plant Telomere Binding Proteins. CURRENT PROTEIN & PEPTIDE SCIENCE, BENTHAM SCIENCE PUBL LTD, 12, 2, od s. 75-83, 9 s. ISSN 1389-2037. 2011. info
MAJERSKÁ, Jana a Eva SÝKOROVÁ a Jiří FAJKUS. Non-telomeric activities of telomerase. MOLECULAR BIOSYSTEMS, Cambridge: RSC Publishing, 7, 4, od s. 1013-1023, 11 s. ISSN 1742-206X. 2011. doi:10.1039/c0mb00268b. URL info
MAJEROVÁ, Eva a Miloslava FOJTOVÁ a Iva MOZGOVÁ a Miroslava BITTOVÁ a Jiří FAJKUS. Hypomethylating drugs efficiently decrease cytosine methylationin telomeric DNA and activate telomerase without affectingtelomere lengths in tobacco cells. Plant Molecular Biology, Springer, 77, 4-5, od s. 371-380, 10 s. ISSN 0167-4412. 2011. doi:10.1007/s11103-011-9816-7. info
MAJEROVÁ, Eva a Miloslava FOJTOVÁ a Terezie MANDÁKOVÁ a Jiří FAJKUS. Methylation of plant telomeric DNA: what do the results say? Plant Molecular Biology, Springer, 77, 6, od s. 533-536, 4 s. ISSN 0167-4412. 2011. doi:10.1007/s11103-011-9834-5. info
CRHÁK KHAITOVÁ, Lucie a Miloslava FOJTOVÁ a Kateřina KŘÍŽOVÁ a Jana LUNEROVÁ a Jaroslav FULNEČEK a Anna DEPICKER a Aleš KOVAŘÍK. Paramutation of tobacco transgenes by small RNA-mediated transcriptional gene silencing. Epigenetics, Austin: Landes Bioscience, 6, 5, od s. 650-660, 11 s. ISSN 1559-2294. 2011. doi:10.4161/epi.6.5.15764. info
FOJTOVÁ, Miloslava a Vratislav PEŠKA a Zuzana DOBŠÁKOVÁ a Iva MOZGOVÁ a Jiří FAJKUS a Eva SÝKOROVÁ. Molecular analysis of T-DNA insertion mutants identified putative regulatory elements in the AtTERT gene. Journal of Experimental Botany, Oxford: Oxford University Press, 62, 15, od s. 5531-5545, 15 s. ISSN 0022-0957. 2011. doi:10.1093/jxb/err235. info
PERNICOVÁ, Zuzana a Eva SLÁBÁKOVÁ a Gvantsa KHARAISHVILI a Jan BOUCHAL a Milan KRÁL a Zuzana KUNICKÁ a Miroslav MACHALA a Alois KOZUBÍK a Karel SOUČEK. Androgen Depletion Induces Senescence in Prostate Cancer Cells through Down-regulation of Skp2. Neoplasia, Neoplasia Press, 13, 6, od s. 526-536, 11 s. ISSN 1522-8002. 2011. doi:10.1593/neo.11182. URL info
VOHÁŇKA, Stanislav a Josef BEDNAŘÍK a Daniela PÁCLOVÁ a Jana SEDLÁČKOVÁ a Lenka FAJKUSOVÁ. Congenital Myotonia Caused by Mutations in the CIC-1 Chloride Channel Gene. Ceska a slovenska neurologie a neurochirurgie, 74, 4, od s. 467-470, 4 s. ISSN 1210-7859. 2011. info
RAPOPORT, Alexandra E. a Zakharia M. FRENKEL a Eduard TRIFONOV. Nucleosome Positioning Pattern Derived from Oligonucleotide Compositions of Genomic Sequences. Journal of Biomolecular Structure & Dynamics, Adenine Press, 28, 4, od s. 567-574, 8 s. ISSN 0739-1102. 2011. info
KOREN, Zohar a Eduard TRIFONOV. Role of Everlasting Triplet Expansions in Protein Evolution. JOURNAL OF MOLECULAR EVOLUTION, New York: Springer, 72, 2, od s. 232-239, 8 s. ISSN 0022-2844. 2011. doi:10.1007/s00239-010-9425-0. info
TRIFONOV, Eduard. Cracking the chromatin code: Precise rule of nucleosome positioning. PHYSICS OF LIFE REVIEWS, Elsevier Science, 8, 1, od s. 39-50, 12 s. ISSN 1571-0645. 2011. doi:10.1016/j.plrev.2011.01.004. info
BETTECKEN, Thomas a Zakharia M. FRENKEL a Eduard TRIFONOV. Human nucleosomes: special role of CG dinucleotides and Alu-nucleosomes. BMC Genomics, London: BioMed Central Ltd, 2011, 12, od s. "nestránkováno", 5 s. ISSN 1471-2164. 2011. doi:10.1186/1471-2164-12-273. URL info
FRENKEL, Zakharia M. a Thomas BETTECKEN a Eduard TRIFONOV. Nucleosome DNA sequence structure of isochores. BMC Genomics, London: BioMed Central Ltd, 12, 203, od s. "nestránkováno", 6 s. ISSN 1471-2164. 2011. doi:10.1186/1471-2164-12-203. info
HAPALA, Jan a Eduard TRIFONOV. High resolution positioning of intron ends on the nucleosomes. Gene, Elsevier, 489, 1, od s. 6-10, 5 s. ISSN 0378-1119. 2011. doi:10.1016/j.gene.2011.08.022. info
RAPOPORT, Alexandra E. a Eduard TRIFONOV. "Anticipated" nucleosome positioning pattern in prokaryotes. Gene, Elsevier, 488, 1-2, od s. 41-45, 5 s. ISSN 0378-1119. 2011. doi:10.1016/j.gene.2011.08.002. info
TRIFONOV, Eduard. Vocabulary of Definitions of Life Suggests a Definition. Journal of Biomolecular Structure & Dynamics, Adenine Press, 29, 2, od s. 259-266, 8 s. ISSN 0739-1102. 2011. URL info
FRENKEL, Zakharia M. a Eduard TRIFONOV a Zeev VOLKOVICH a Thomas BETTECKEN. Nucleosome Positioning Patterns Derived from Human Apoptotic Nucleosomes. Journal of Biomolecular Structure & Dynamics, Adenine Press, 29, 3, od s. 577-583, 7 s. ISSN 0739-1102. 2011. info
PINO, Samanta a Eduard TRIFONOV a Di Ernesto MAURO. On the Observable Transition to Living Matter. Genomics, Proteomics & Bioinformatics, Elsevier Ltd., 9, 1-2, od s. 7-14, 8 s. ISSN 1672-0229. 2011. doi:10.1016/S1672-0229(11)60002-8. info
TRIFONOV, Eduard a Victor B. ZHURKIN. Jon Widom, the Scientist In Memoriam. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, Adenine Press, 29, 2, od s. 257-258, 2 s. ISSN 0739-1102. 2011. URL info
MOZGOVÁ, Iva a Petra PROCHÁZKOVÁ SCHRUMPFOVÁ a Ctirad HOFR a Jiří FAJKUS. Functional characterization of domains in AtTRB1, a putative telomere-binding protein in Arabidopsis thaliana. Phytochemistry, England: Pergamon-Elsevier Science Ltd, 69, 9s. 1814-1819. ISSN 0031-9422. 2008. info
PROCHÁZKOVÁ SCHRUMPFOVÁ, Petra a Iva MOZGOVÁ a Milan KUCHAŘ a Jan PALEČEK a Jiří FAJKUS. Alternative telomere lengthening in development of normal and telomerase knock-out plants. In 4th European workshop on: Role of Telomeres and Telomerase in Cancer and Aging. 2008. info
FAJKUSOVÁ, Lenka a Zdeněk LUKÁŠ a Miroslava TVRDÍKOVÁ a Viera KUHROVÁ a Jiří HÁJEK a Jiří FAJKUS. Novel dystrophin mutations revealed by analysis of dystrophin mRNA: alternative splicing suppresses the phenotypic effect of a nonsense mutation. Neuromuscular Disordes, Amsterdam: Elsevier Science, roč. 11, 2s. 133-138. ISSN 0960-8966. 2001. info
FAJKUS, Jiří a Edward N. TRIFONOV. Columnar Packing of Telomeric Nucleosomes. Biochemical and Biophysical Research Communications, California: Academic Press, roč. 280, 4s. 961-963. ISSN 0006-291X. 2001. info
DVOŘÁKOVÁ, Dana a Pavel KREJČÍ a Jiří MAYER a Jiří FAJKUS a Aleš HAMPL a Petr DVOŘÁK. Changes in the expression of FGFR3 in patients with chronic myeloid leukaemia receiving transplants of allogeneic peripheral blood stem cells. British Journal of Haematology, Oxford: Blackwell Science Ltd, roč. 113, Februarys. 832-835. ISSN 0007-1048. 2001. info
SÝKOROVÁ, Eva a Jiří FAJKUS a Ito MIKAKO a Kiichi FUKUI. Transition between two forms of heterochromatin at plant subtelomeres. Chromosome Research, Dordrecht: Kluwer Academic Publishers, roč. 9, Januarys. 309-323. ISSN 0967-3849. 2001. info
FULNEČKOVÁ, Jana a Jiří FAJKUS. Inhibition of plant telomerase by telomere-binding proteins from nuclei of telomerase-negatative tissues. FEBS letters : for the rapid publication of short reports in biochemistry, biophysics and molecular biology, Amsterdam: North-Holland, 467, 2-3s. 305-310. ISSN 0014-5793. 2000. info
FAJKUSOVÁ, Lenka a Jiří FAJKUS a Klára POLÁČKOVÁ a Jaroslav FULNEČEK a Dana DVOŘÁKOVÁ a Eva KRAHULCOVÁ. Detailed Mapping of Methylcythosine Positions at the CpG Island Surrounding tha Pa Promoter at the bcr-abl Locus in CML Patients in Two Cell Lines, K562 and BV 173. Blood Cells, Molecules and Diseases, Orlando, Florida: Academic Press, 26, 3s. 193-204. ISSN 1079-9796. 2000. info
ŘÍHA, Karel a Thomas MCKNIGHT a Jiří FAJKUS a Boris VYSKOT a Dorothy E. SHIPPEN. Analysis of the G-overhang structures on plant telomeres: evidence for two distinct telomere architectures. The Plant Journal, Velká Británie: Blackwell Science Ltd, 23, 5s. 633-641. ISSN 0960-7412. 2000. info
SÝKOROVÁ, Eva a Mirka HORÁKOVÁ a I. MIKAKO a K. FUKUI a Jiří FAJKUS. DNA and Chromatin Structure of Telomere-Subtelomere Junctions in Silene latifolia. J.Biomol. Struct. Dyn., USA: Adenine press, 17, 6s. 1155-1155. ISSN 0739-1102. 2000. info
MALÁSKA, Jan a Marie SKLENIČKOVÁ a Kateřina KREJČÍ a Lenka FAJKUSOVÁ a Milan BAJER a Hana HRSTKOVÁ a Jiří FAJKUS. Telomerase Activity and Expresion and Telomere Analysis in Situ in the Course of Treatment of Childhood Leukemias. Blood Cells, Molecules and Diseases, Orlando, Florida: Academic Press, 26, 5s. 534-539. ISSN 1079-9796. 2000. info
HORÁKOVÁ, Mirka a Jiří FAJKUS. TAS49-a dispersed repetitive sequence isolated from subtelomeric regions of Nicotiana tomentosiformis chromosomes. Genome, Canada: NRC Canada, 43, 2s. 273-283. ISSN 0831-2796. 1999. info
ŘÍHA, Karel a Jiří FAJKUS a Jiří ŠIROKÝ a Boris VYSKOT. Developmental Control of Telomere Lengths and Telomerase Activity in Plants. The Plant Cell, American Society of Plant Physiologists, 10, 10s. 1691-1698. ISSN 1040-4651. 1998. URL info
FAJKUS, Jiří a Jana FULNEČKOVÁ a Mirka HORÁKOVÁ a Klára POLÁČKOVÁ a Karel ŘÍHA a Roman MATYÁŠEK. Plant cells express telomerase activity upon transfer to callus culture, without extensively changing telomere lengths. Molecular and General Genetics, 260, 5s. 470-474. ISSN 0026-8925. 1998. info
FAJKUS, Jiří a Janice NICLAS a Ronald HANCKOCK. DNA loop domains in a 1.4-Mb region around the human hprt gene mapped by cleavage mediated by nuclear matrix-associated topoisomerase II. Molecular and General Genetics, 260, 5s. 410-416. ISSN 0026-8925. 1998. info

Last update: 2001/11/28

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