Publication details
c
-Myb regulates MMP1, MMP9 and cathepsin D: Implications for the matrix-dependent breast cancer cell invasion and metastasis
| Basic information | |
|---|---|
| Original title: | c-Myb regulates MMP1, MMP9 and cathepsin D: Implications for the matrix-dependent breast cancer cell invasion and metastasis |
| Authors: | Lucia Knopfová, Petr Beneš, Lucie Pekarčíková, Markéta Hermanová, Michal Masařík, Karel Souček, Jan Šmarda |
| Further information | |
|---|---|
| Citation: | KNOPFOVÁ, Lucia - BENEŠ, Petr - PEKARČÍKOVÁ, Lucie - HERMANOVÁ, Markéta - MASAŘÍK, Michal - SOUČEK, Karel - ŠMARDA, Jan. c-Myb regulates MMP1, MMP9 and cathepsin D: Implications for the matrix-dependent breast cancer cell invasion and metastasis. 2011. |
| Original language: | English |
| Field: | Genetics and molecular biology |
| Type: | Conference abstract |
| Keywords: | c-Myb; breast cancer; cell invasion; metastasis |
Ectopically expressed c-Myb enhanced motility and ability of human MDA-MB-231 and mouse 4T1 mammary cancer cells to invade Matrigel but not the collagen I matrix in vitro. c-Myb strongly increased expression/activity of cathepsin D and matrix metalloproteinase (MMP) 9 and significantly down-regulated MMP1. The gene coding for cathepsin D was identified as direct c-Myb-target gene and downstream effector of the c-Myb migration-promoting function. Finally, we demonstrated that c-Myb delayed growth of mammary tumors in BALB/c mice and affected metastatic potential of breast cancer cells in an organ-specific manner. This study demonstrates potential role of a stromal context for the c-Myb function in control of breast cancer invasion and metastasis.
Related projects:
- Molecular basis of cell and tissue regulations
- Molecular mechanisms of the cell proliferation and differentiation
- Mechanism of procathepsin D effect on breast cancer cells
- The role of c-Myb and Cox-2 proteins in colon carcinogenesis
