prof. MUDr. Mgr. Marek Mráz, Ph.D.

2022

• Versatile coculture systém to study chronic lymhocytic leukemia proliferation.

  HOFERKOVÁ Eva KADÁKOVÁ Soňa ŠEDA Václav LOJA Tomáš MLADONICKÁ PAVLASOVÁ Gabriela VERNER Jan CHOCHOLA Václav JAROŠ Josef LIŠKOVÁ Květoslava FILIP Daniel VEČEŘA Josef FARIA ZENI Pedro DORAZILOVÁ Jana ONDROUŠKOVÁ Eva ONDRIŠOVÁ Laura BOUDNÝ Miroslav KŘEN Leoš VOJTOVÁ Lucy MAYER Jiří MRÁZ Marek

  Conference abstract

  Year: 2022, type: Conference abstract

2021

• FoxO1-GAB1 axis regulates homing capacity and tonic AKT activity in chronic lymphocytic leukemia

  ŠEDA Václav VOJÁČKOVÁ Eva ONDRIŠOVÁ Laura KOŠŤÁLOVÁ Lenka SHARMA Sonali LOJA Tomáš MLADONICKÁ PAVLASOVÁ Gabriela ZICHA Daniel KUDLIČKOVÁ PEŠKOVÁ Marie KŘIVÁNEK Jan MATULOVÁ Květoslava KŘEN Leoš BENES V. LITZMANOVÁ Markéta BORSKÝ Marek OPPELT Jan VERNER Jan POSPÍŠILOVÁ Šárka BRYCHTOVÁ Yvona PANOVSKÁ Anna TAN Z. ZHANG S.X. DOUBEK Michael AMRUZ ČERNÁ Kateřina MAYER Jiří MRÁZ Marek

  Article in Periodical

  Blood, year: 2021, volume: 138, edition: 9, DOI

• FoxO1-GAB1 Axis Regulates Homing Capacity and Tonic AKT Activity in Chronic Lymphocytic Leukemia: Novel Therapeutic Target.

  ŠEDA Václav VOJÁČKOVÁ E. ONDRIŠOVÁ Laura KOŠŤÁLOVÁ Lenka SHARMA Sonali LOJA Tomáš ZICHA Daniel VERNER Jan POSPÍŠILOVÁ Šárka BRYCHTOVÁ Yvona PANOVSKÁ Anna TAN Zhuowen ZHANG Shelley DOUBEK Michael MAYER Jiří MRÁZ Marek

  Conference abstract

  Year: 2021, type: Conference abstract

• GAB1 – novel regulator of migration capacity and tonic AKT activity in CLL: Implications for combinatorial therapy with BCR inhibitors.

  ŠEDA Václav HOFERKOVÁ Eva ONDRIŠOVÁ Laura KOŠŤÁLOVÁ Lenka SHARMA Sonali LOJA Tomáš ZICHA Daniel VERNER Jan POSPÍŠILOVÁ Šárka BRYCHTOVÁ Yvona PANOVSKÁ Anna DOUBEK Michael MAYER Jiří MRÁZ Marek

  Conference abstract

  Year: 2021, type: Conference abstract

• GAB1 Regulates homing capacity and tonic AKT activity in chronic lymphocytic leukemia: novel therapeutic target

  MRÁZ Marek ŠEDA Václav HOFERKOVÁ Eva ONDRIŠOVÁ Laura KOŠŤÁLOVÁ Lenka SHARMA Sonali LOJA Tomáš ZICHA Daniel VERNER Jan POSPÍŠILOVÁ Šárka BRYCHTOVÁ Yvona PANOVSKÁ Anna DOUBEK Michael MAYER Jiří

  Conference abstract

  Year: 2021, type: Conference abstract

• GAB1 reguluje tonickou AKT signalizaci a migraci buněk chronické lymfatické leukémie: implikace pro kombinační léčbu s BCR inhibitory.

  ŠEDA Václav VOJÁČKOVÁ Eva ONDRIŠOVÁ Laura KOŠŤÁLOVÁ Lenka SHARMA Sonali LOJA Tomáš ZICHA D. VERNER Jan POSPÍŠILOVÁ Šárka BRYCHTOVÁ Yvona PANOVSKÁ Anna TAN Zhuowen ZHANG Shelley DOUBEK Michael MAYER Jiří MRÁZ Marek

  Conference abstract

  Year: 2021, type: Conference abstract

• Ibrutinib Blocks CD40 Signalling in CLL in Vivo by Reducing TRAF4 Levels.

  SHARMA Sonali MLADONICKÁ PAVLASOVÁ Gabriela ŠEDA Václav AMRUZ ČERNÁ Kateřina HOFERKOVÁ Eva FILIP Daniel ONDRIŠOVÁ Laura ŠANDOVÁ Veronika KOŠŤÁLOVÁ Lenka FARIA ZENI Pedro BORSKÝ Marek OPPELT Jan LISKOVA K. KŘEN Leoš JANÍKOVÁ Andrea POSPÍŠILOVÁ Šárka FERNANDES S. SHEHATA M. RASSENTI L. JAEGER U. DOUBEK Michael DAVIDS M. BROWN J. MAYER Jiří KIPPS T. MRÁZ Marek

  Conference abstract

  Year: 2021, type: Conference abstract

• Ibrutinib blocks CD40 signalling in malignant B cells by reducing TRAF4 levels.

  MRÁZ Marek

  Conference abstract

  Year: 2021, type: Conference abstract

• IL4-STAT6 signaling induces CD20 in chronic lymphocytic leukemia and this axis is repressed by PI3K delta inhibitor idelalisib

  ŠANDOVÁ Veronika MLADONICKÁ PAVLASOVÁ Gabriela ŠEDA Václav AMRUZ ČERNÁ Kateřina SHARMA Sonali PALUŠOVÁ Veronika BRYCHTOVÁ Yvona POSPÍŠILOVÁ Šárka FERNANDES S.M. PANOVSKÁ Anna DOUBEK Michael DAVIDS M.S. BROWN J.R. MAYER Jiří MRÁZ Marek

  Article in Periodical

  haematologica, year: 2021, volume: 106, edition: 11, DOI

• IL4-STAT6 Signaling Induces CD20 in Chronic Lymphocytic Leukemia and This Axis Is Repressed by PI3Kδ Inhibitor Idelalisib.

  ŠANDOVÁ Veronika MRÁZ Marek MLADONICKÁ PAVLASOVÁ Gabriela ŠEDA Václav PALUŠOVÁ Veronika BRYCHTOVÁ Yvona FERNANDES S. DOUBEK Michael DAVIDS M. BROWN J.

  Conference abstract

  Year: 2021, type: Conference abstract