Project information
Environment - carcinogenesis - oncology
- Project Identification
- MSM 141100003
- Project Period
- 1/1999 - 1/2004
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Faculty of Medicine
- Keywords
- environmental pollutants; genotoxic agents; mechanisms of genomic and extragenomic carcinogenesis; predictive bioparameters ; optimization of oncological therapy
The aim of this multidisciplinary project is to contribute to the research of the mechanisms of carcinogenesis with a special interest devoted to reduction of risks from environmental pollutants and genotoxic effects of therapeutic agents. The investigation of effects of persistent organic pollutants and other genotoxic compounds on induction and development of malignant tumors. The special interest will be paid also to the process of extragenomic carcinogenesis. Biomathematical analysis of risks of genotoxicity in their real proportions, which couples the data from basic environmental reasearch, toxicology, experimental biology and clinical oncology. Multivariate mathematical analysis of oncological bioparameters directed mainly to prediction of the efficacy of treatment in different types of tumors and optimization of therapeutic regimens.
Publications
Total number of publications: 670
2001
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Quality of the natural environment in the Czech Republic at the regional level. Results of the Košetice Observatory
Year: 2001, number of pages: 189 s.
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Regional background monitoring of PBT compounds. The comparison of the results from measurements and monitoring
Environmental Science and Pollution Research, year: 2001, volume: 8, edition: 3
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Regional background monitoring of PBTs in Central Europe and comparison with model results. Workshop Slowly degradable organics in the atmospheric environment and air-sea exchange
Year: 2001, number of pages: 6 s.
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Regional background monitoring of persistent, bioaccumulative and toxic compounds in Central Europe - I:Overview of 12 years of TOCOEN project
Meteorologický časopis, year: 2001, volume: 4, edition: 2
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Regionální pozaďový monitoring persistentních, bioakumulativních a toxických látek ve střední Evropě - srovnání výsledků z měření a modelování
OVZDUŠÍ 2001 - Program a sborník konference, year: 2001
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Relation of prenephrectomy CD profiles and serum cytokines to the disease outcome and response to IFN-alpha/IL-2 therapy in renal cell carcinoma patients
Oncol. Rep., year: 2001, volume: 8, edition: 3
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Rizika nehod s výskytem toxických chemických látek a úloha dekontaminace při záchranných a likvidačních pracích.
V. Mezinárodní konference Medicina katastrof Zlín-Lukov 2001, Sborník přednášek, year: 2001
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Role of international organisations in combatting terrorism.
The 1st World Congress on Chemical and Biological Terrorism, year: 2001
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Role of the Faculty of Chemistry, Brno University of Technology in solution of the methods of detection, identification,decontamination and protection against toxic compounds and liquidation of former contaminated environment.
7th International Symposium on Protection against Chemical and Biological Warfare Agents, year: 2001
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Roots and early traditions of university chemical education in Brno, capital of Moravia
53. Zjazd chemických společností, Banská Bystrica 2001. Zborník prispevkov 1, year: 2001