Publication details
Diagnostický a prognostický význam biomarkerů u pacientů s akutním koronárním syndromem v současné klinické praxi
| Title in English | Biomarkers in Acute Coronary Syndrome |
|---|---|
| Authors | |
| Year of publication | 2013 |
| Type | Article in Periodical |
| Magazine / Source | Acta Medicinae : Kardiologie |
| MU Faculty or unit | |
| Citation | |
| Field | Cardiovascular diseases incl. cardiosurgery |
| Keywords | Acute coronary syndrome; Biomarkers |
| Description | Biomarkers are necessary in diagnostics of acute coronary syndrome (ACS). Acute myocardial infarction is defined as the myocardial necrosis because of acute myocardial ischemia. Most common cause of myocardial ischemia is a rupture of aterosclerotic plaque with trombosis. Ischemia can be caused also secondarily during lack of oxygen in myocardium, e.g. anemia, hypotension, hypertension, respiratory failure, coronary artery embolism, during coronary spasm and tachyarrhytmias or bradyarrhytmias. Acute myocardial infarction can also occure during revascularization surgery or PCI and can also lead into acute cardiac death. Cardiac specific biomarkers are used to detect myocardial necrosis. These biomarkers are troponin or CK-MB. Cardiac specific biomarkers are also important for risk stratification of pacients with ACS. The most common biomarkers for this purpose are troponins, natriuretic peptides and C-reactive protein. The aim of this article is to summarize the clinical use of biomarkers. |