Publication details
Ularitid v léčbě akutně dekompenzovaného srdečního selhání - výsledky studie TRUE-AHF
| Title in English | Ularitide in the treatment of acute heart failure decompensation - results of the TRUE-AHF trial |
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| Authors | |
| Year of publication | 2017 |
| Type | Article in Periodical |
| Magazine / Source | Kardiologická revue - Interní medicína |
| MU Faculty or unit | |
| Citation | |
| Field | Cardiovascular diseases incl. cardiosurgery |
| Keywords | acute heart failure decompensation; ularitide |
| Description | The primary hypothesis of the study was that ventricular distension during acute heart failure leads to myocardial injury, which would explain why such episodes of acute decompensation accelerate or worsen the course of the disease. The results showed that early vasodilation leads to significant decongestion and reduces cardiac-wall stress and rates of in-hospital worsening of heart failure. However, this positive effect did not reduce myocardial injury, nor did it change the prognosis of these patients, including the long-term risk of cardiovascular death. |