Publication details
Úloha a možnosti použití imunoterapie u dětských onkologických pacientů
| Title in English | The role and possibilities of using immunotherapy in pediatrie cancer patients |
|---|---|
| Authors | |
| Year of publication | 2017 |
| Type | Article in Periodical |
| Magazine / Source | Onkologická revue |
| MU Faculty or unit | |
| Citation | |
| Field | Oncology and hematology |
| Keywords | pediatric cancer; immunotherapy monoclonal antibodies; vaccines; cell therapy; cytokines |
| Description | Currently the most children with cancer can be cured with standard therapy (surgery, chemotherapy, radiotherapy). The only limiting factor is its severe acute toxicity and late adverse events. In pediatric oncology immunotherapy has some delay, but the initial clinical trials of immunotherapy show a good tolerance and promising results, specially in the setting of refractory or recurrent high-risk tumors. In this article we will discuss a current situation in pediatric oncology, what immunotherapies are being tested in the clinical practice, from monoclonal antibodies, check-point inhibitors to tumor vaccines, chimeric antigene receptors, cytokines and innate immunity. |