Publication details
Undescribed Amaryllidaceae Alkaloids from <i>Zephyranthes citrina</i> and Their Cytotoxicity
| Authors | |
|---|---|
| Year of publication | 2024 |
| Type | Article in Periodical |
| Magazine / Source | Journal of Natural Products |
| MU Faculty or unit | |
| Citation | |
| Web | https://pubs.acs.org/doi/epdf/10.1021/acs.jnatprod.4c00825?ref=article_openPDF |
| Doi | http://dx.doi.org/10.1021/acs.jnatprod.4c00825 |
| Keywords | CHEMICAL-CONSTITUENTSAPOPTOSISCRINUMHAEMANTHAMINE |
| Description | This phytochemical study presents the isolation of eight alkaloids from Zephyranthes citrina Baker. The structures of the new alkaloids, zephycitrine (1) and 6-oxonarcissidine (2), were established by analysis of spectroscopic and spectrometric data. Processing the EtOH extract under acid-base conditions yielded the unreported isolation artifacts 3 and 4. This work also provides analytical data for alkaloids not properly described in the literature (5 and 6). The hippeastidine/zephyranine scaffolds in derivatives 3, 4, and 8-10 are also thoroughly discussed. Furthermore, a cytotoxicity screening of 25 Amaryllidaceae alkaloids isolated from Z. citrina was performed. Only the known alkaloids haemanthamine (12), haemanthidine (13), and lycorine (27) showed significant cell growth inhibition. |