Publication details
Nové poznatky v etiologii, patogenezi a diagnostice VPMD
| Title in English | New insights into the etiology, pathogenesis and diagnosis of AMD |
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| Authors | |
| Year of publication | 2005 |
| Type | Conference abstract |
| MU Faculty or unit | |
| Citation | |
| Description | In a study of aetiopathogenesis of AMD occurred in the last 10 years a significant shift. It was found that the influence of age is to reduce the number of cells of the retinal pigment epithelium (PE). This leads to a reduction in the number of melanosomes, which have a protective effect against the toxic effects of blue light in particular. Due to the increasing age is the accumulation of lipofuscin, protein of aging; the activation of free oxygen radicals leads to acceleration the process of apoptosis (natural cell death). Another pathogenetic mechanism playing a major role is to decrease the permeability of Bruch's membrane. This condition is caused by deposition of waste products of PE cells (granular and vesicular structures). If there is a significant reduction in local permeability of Bruch's membrane, formed between the surface layer of cells, PE and others. They may have the appearance of his solitary or confluent nature. Solitary drusen of size 63 um are known as hard, confluent greater than 63 um then as soft. The incidence of drusen means already in itself a very serious inroad into the retinal architecture, which in effect may then lead to the rupture of Bruch's membrane complex formation of CNV. Crucial role plays in this case vascular factors, particularly vascular endothelial growth factor (VEGF). For the normal function of the retina is necessary balance between production and the need for VEGF. In old age but occurs due to the reduced throughput Bruch's membrane overproduction of VEGF in retina and therefore stimulation of the neovascular complex. |