Informace o publikaci
3rd ICCTI Workshop - MicroRNAs in Oncology
| Autoři | |
|---|---|
| Rok publikování | 2012 |
| Druh | Uspořádání workshopu |
| Fakulta / Pracoviště MU | |
| Citace | |
| Popis | MicroRNAs (miRNAs) are small non-coding RNAs 18-25 nucleotides in length that downregulate gene expression during various crucial cell processes such as apoptosis, differentiation and developmnet. Changes in the expression profiles of miRNAs have been observed in a variety of human solidtumors and hametological malignancies. Functional studies indicate that miRNAs act as tumor suppressors and oncogenes. These findings significantly extend concept of molecular pathogenesis of cancer and have shown great potential for miRNA as a novel class of therapeutic targets. |