Informace o publikaci

Patient-Derived Xenograft Models: An Emerging Platform for Translational Cancer Research

Autoři	HIDALGO Manuel AMANT Frederic BIANKIN Andrew V. BUDINSKÁ Eva BYRNE Annete T. CALDAS Carlos CLARKE Robert B. JONG Steven de JONKERS Jos MAELANDSMO Gundhild Mari ROMAN-ROMAN Sergio SEOANE Joan TRUSOLINO Livio VILLANUEVA Alberto
Rok publikování	2014
Druh	Článek v odborném periodiku
Časopis / Zdroj	Cancer Discovery
Fakulta / Pracoviště MU	Lékařská fakulta
Citace
Doi	http://dx.doi.org/10.1158/2159-8290.CD-14-0001
Obor	Onkologie a hematologie
Klíčová slova	HUMAN PANCREATIC-CANCER; TUMOR XENOGRAFTS; NUDE-MICE; COLORECTAL-CANCER; STEM-CELLS; IN-VIVO; PERSONALIZED CHEMOTHERAPY; THERAPEUTIC RESPONSE; IMMUNODEFICIENT MICE; DRUG DEVELOPMENT
Popis	Recently, there has been an increasing interest in the development and characterization of patient-derived tumor xenograft (PDX) models for cancer research. PDX models mostly retain the principal histologic and genetic characteristics of their donor tumor and remain stable across passages. These models have been shown to be predictive of clinical outcomes and are being used for preclinical drug evaluation, biomarker identification, biologic studies, and personalized medicine strategies. This article summarizes the current state of the art in this field, including methodologic issues, available collections, practical applications, challenges and shortcomings, and future directions, and introduces a European consortium of PDX models. Significance: PDX models are increasingly used in translational cancer research. These models are useful for drug screening, biomarker development, and the preclinical evaluation of personalized medicine strategies. This review provides a timely overview of the key characteristics of PDX models and a detailed discussion of future directions in the field.