Informace o publikaci

Safety of early endarterectomy in patients with symptomatic carotid artery stenosis: an international multicenter study

Autoři	TSIVGOULIS G. KROGIAS C. GEORGIADIS G.S. MIKULÍK Robert SAFOURIS A. MEVES S.H. VOUMVOURAKIS K. HARŠÁNY Michal STAFFA Robert PAPAGEORGIOU S.G. KATSANOS A.H. LAZARIS A. MUMME A. LAZARIDES M. VASDEKIS S.N.
Rok publikování	2014
Druh	Článek v odborném periodiku
Časopis / Zdroj	European Journal of Neurology
Fakulta / Pracoviště MU	Lékařská fakulta
Citace
Doi	http://dx.doi.org/10.1111/ene.12461
Obor	Neurologie, neurochirurgie, neurovědy
Klíčová slova	carotid artery; carotid endarterectomy; early; stroke
Popis	Although the latest recommendations suggest that carotid endarterectomy (CEA) should be performed in symptomatic carotid artery stenosis (sCAS) patients within 2weeks of the index event, only a minority of patients undergo surgery within the recommended time-frame. The aim of this international multicenter study was to prospectively evaluate the safety of early CEA in patients with sCAS in everyday clinical practice settings. Consecutive patients with non-disabling acute ischaemic stroke (AIS) or transient ischaemic attack (TIA) due to sCAS (70%) underwent early (14days) CEA at five tertiary-care stroke centers during a 2-year period. Primary outcome events included stroke, myocardial infarction (MI) or death occurring during the 30-day follow-up period and were defined according to the International Carotid Stenting Study criteria. A total of 165 patients with sCAS [mean age 6910years; 69% men; 70% AIS; 6% crescendo TIA; 8% with contralateral internal carotid artery (ICA) occlusion] underwent early CEA (median elapsed time from symptom onset 8days). Urgent CEA (2days) was performed in 20 cases (12%). The primary outcomes of stroke and MI were 4.8% [95% confidence interval (CI) 1.5%-8.1%] and 0.6% (95% CI 0%-1.8%). The combined outcome event of non-fatal stroke, non-fatal MI or death was 5.5% (95% CI 2.0%-9.0%). Crescendo TIA, contralateral ICA occlusion and urgent CEA were not associated (P>0.2) with a higher 30-day stroke rate. Our findings indicate that the risk of early CEA in consecutive unselected patients with non-disabling AIS or TIA due to sCAS is acceptable when the procedure is performed within 2weeks (or even within 2days) from symptom onset. Click for the corresponding questions to this CME article.