Informace o publikaci

Nonsense-Mediated mRNA Decay Modulates Immune Receptor Levels to Regulate Plant Antibacterial Defense

Autoři	GLOGGNITZER J. AKIMCHEVA S. SRINIVASAN A. KUSENDA B. RIEHS N. STAMPFL H. BAUTOR J. DEKROUT B. JONAK C. JIMENEZ-GOMEZ J.M. PARKER J.E. ŘÍHA Karel
Rok publikování	2014
Druh	Článek v odborném periodiku
Časopis / Zdroj	CELL HOST & MICROBE
Fakulta / Pracoviště MU	Středoevropský technologický institut
Citace
www	http://www.sciencedirect.com/science/article/pii/S1931312814003023
Doi	http://dx.doi.org/10.1016/j.chom.2014.08.010
Obor	Genetika a molekulární biologie
Klíčová slova	DISEASE RESISTANCE; GENE-EXPRESSION; ENCODING GENES; HUMAN-CELLS; ARABIDOPSIS; NMD; BINDING; GROWTH; UPF1; INHIBITION
Popis	Nonsense-mediated mRNA decay (NMD) is a conserved eukaryotic RNA surveillance mechanism that degrades aberrant mRNAs. NMD impairment in Arabidopsis is linked to constitutive immune response activation and enhanced antibacterial resistance, but the underlying mechanisms are unknown. Here we show that NMD contributes to innate immunity in Arabidopsis by controlling the turnover of numerous TIR domain-containing, nucleotide-binding, leucine-rich repeat (TNL) immune receptor-encoding mRNAs. Autoimmunity resulting from NMD impairment depends on TNL signaling pathway components and can be triggered through deregulation of a single TNL gene, RPS6. Bacterial infection of plants causes host-programmed inhibition of NMD, leading to stabilization of NMD-regulated TNL transcripts. Conversely, constitutive NMD activity prevents TNL stabilization and impairs plant defense, demonstrating that host-regulated NMD contributes to disease resistance. Thus, NMD shapes plant innate immunity by controlling the threshold for activation of TNL resistance pathways.