Informace o publikaci
Endocrine Disrupting Compounds Affecting Corticosteroid Signaling Pathways in Czech and Swiss Waters: Potential Impact on Fish
| Autoři | |
|---|---|
| Rok publikování | 2014 |
| Druh | Článek v odborném periodiku |
| Časopis / Zdroj | ENVIRONMENTAL SCIENCE & TECHNOLOGY |
| Fakulta / Pracoviště MU | |
| Citace | |
| www | http://pubs.acs.org/doi/abs/10.1021/es502711c |
| Doi | http://dx.doi.org/10.1021/es502711c |
| Obor | Znečištění a kontrola vody |
| Klíčová slova | ENVIRONMENTAL RISK-ASSESSMENT; TANDEM MASS-SPECTROMETRY; SEWAGE-TREATMENT PLANTS; ZEBRAFISH DANIO-RERIO; RAINBOW-TROUT; WASTE-WATER; GLUCOCORTICOID-RECEPTOR; GENE-EXPRESSION; ONCORHYNCHUS-MYKISS; SURFACE WATERS |
| Popis | This study investigated the occurrence of corticosteroid signaling disruptors in wastewaters and rivers in the Czech Republic and in Switzerland. 36 target compounds were detected using HPLC-MS/MS, with up to 6.4 mu g/L for azole antifungals that indirectly affect corticosteroid signaling. Glucocorticoid receptor (GR)-mediated activity was determined using the GR-CALUX bioassay with dexamethasone equivalent concentrations ranging from |
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