Informace o publikaci
Crystal Structure of Human Enterovirus 71
| Autoři | |
|---|---|
| Rok publikování | 2012 |
| Druh | Článek v odborném periodiku |
| Časopis / Zdroj | Science |
| Fakulta / Pracoviště MU | |
| Citace | |
| Doi | http://dx.doi.org/10.1126/science.1218713 |
| Obor | Mikrobiologie, virologie |
| Klíčová slova | PICORNAVIRUS; RECEPTOR; DISEASE |
| Popis | Enterovirus 71 is a picornavirus associated with fatal neurological illness in infants and young children. Here, we report the crystal structure of enterovirus 71 and show that, unlike in other enteroviruses, the “pocket factor,” a small molecule that stabilizes the virus, is partly exposed on the floor of the “canyon.” Thus, the structure of antiviral compounds may require a hydrophilic head group designed to interact with residues at the entrance of the pocket. |