Informace o publikaci
A draft of bronchoscopic grading system in patients with toxic epidermal necrolysis
| Autoři | |
|---|---|
| Rok publikování | 2017 |
| Druh | Článek v odborném periodiku |
| Časopis / Zdroj | Burns |
| Fakulta / Pracoviště MU | |
| Citace | |
| Doi | http://dx.doi.org/10.1016/j.burns.2017.01.005 |
| Obor | Chirurgie včetně transplantologie |
| Klíčová slova | toxic epidermal necrolysis |
| Popis | Toxic epidermal necrolysis (TEN) is a rare, life-threatening condition, which is caused by the development of massive apoptosis in the dermoepidermal junction [1]. This apoptosis is mainly caused by caspase mechanisms, which are affected by the activity of T-lymphocytes (CD4+ and CD8+), NK cells, or the bond of CD95L to CD95R [2]. Noncaspase mechanisms are also applied in the TEN pathophysiology, e.g., production of granzyme B CD8+ T lymphocytes or NK cells. |