Diagnosis of Multiple Myeloma by Mass Spectrometry of Peripheral Blood Plasma and Artificial Intelligence

• Autoři: DEULOFEU FIGUERAS Meritxell; KOLÁŘOVÁ Lenka; SALVADO Victoria; PENA-MÉNDEZ Eladia Maria; BODAS-VAELLO Pere; POUR Luděk; ŠEVČÍKOVÁ Sabina; ALMÁŠI Martina; HAMPL Aleš; VAŇHARA Petr; HAVEL Josef
• Rok publikování: 2017
• Druh: Další prezentace na konferencích
• Popis: A fast and simple method for the diagnosis of multiple myeloma by the analysis of peripheral blood plasma mass spectra has been developed. It is based on recording the Matrix Assisted Laser Desorption Ionisation Time Of Flight (MALDI TOF) mass spectra of low mass metabolites/compounds (below 2000 Daltons) and the evaluation of these data using Artificial Neural Networks (ANNs). The method, which does not require the identification of biomarkers, has been verified using clinical database of myeloma positive and negative patients.