Informace o publikaci

Clonal selection in the human V delta 1 T cell repertoire indicates gamma delta TCR-dependent adaptive immune surveillance

Autoři	DAVEY M.S. WILLCOX C.R. JOYCE S.P. LADELL K. KASATSKAYA S.A. MCLAREN J.E. HUNTER S. SALIM M. MOHAMMED F. PRICE D.A. CHUDAKOV Dmitriy WILLCOX B.E.
Rok publikování	2017
Druh	Článek v odborném periodiku
Časopis / Zdroj	Nature Communications
Fakulta / Pracoviště MU	Středoevropský technologický institut
Citace
www	https://www.nature.com/articles/ncomms14760.pdf
Doi	http://dx.doi.org/10.1038/ncomms14760
Klíčová slova	STRESS-SURVEILLANCE; ANTIGEN RECOGNITION; CYTOMEGALOVIRUS; RECEPTOR; TRANSPLANTATION; INFECTION; COMPLEX; MEMORY; AGE; DIFFERENTIATION
Popis	gamma delta Tcells are considered to be innate-like lymphocytes that respond rapidly to stress without clonal selection and differentiation. Here we use next-generation sequencing to probe how this paradigm relates to human V delta 2(neg) T cells, implicated in responses to viral infection and cancer. The prevalent V delta 1 T cell receptor (TCR) repertoire is private and initially unfocused in cord blood, typically becoming strongly focused on a few high-frequency clonotypes by adulthood. Clonal expansions have differentiated from a naive to effector phenotype associated with CD27 downregulation, retaining proliferative capacity and TCR sensitivity, displaying increased cytotoxic markers and altered homing capabilities, and remaining relatively stable over time. Contrastingly, V delta 2(+) T cells express semi-invariant TCRs, which are present at birth and shared between individuals. Human V delta 1(+) T cells have therefore evolved a distinct biology from the V delta 2(+) subset, involving a central, personalized role for the gamma delta TCR in directing a highly adaptive yet unconventional form of immune surveillance.