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Function of chromatin structure and dynamics in DNA damage, repair and misrepair: γ-rays andprotons in action
Autoři | |
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Rok publikování | 2014 |
Druh | Článek v odborném periodiku |
Časopis / Zdroj | Applied Radiation and Isotopes |
Citace | |
Doi | http://dx.doi.org/10.1016/j.apradiso.2013.01.022 |
Popis | According to their physical characteristics, protons and ion beams promise a revolution in cancer radiotherapy. Curing protocols however reflect rather the empirical knowledge than experimental data on DNA repair. This especially holds for the spatio-temporal organization of repair processes in the context of higher-order chromatin structure-the problematics addressed in this work. The consequences for the mechanism of chromosomal translocations are compared for gamma rays and proton beams. |
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