Informace o publikaci

Orientation selective deep brain stimulation of the subthalamic nucleus in rats

Autoři	LEHTO Lauri J. CANNA Antonietta WU Lin SIERRA Alejandra ZHURAKOVSKAYA Ekaterina MA Jun PEARCE Clairice SHAIO Maple FILIP Pavel JOHNSON Matthew D. LOW Walter C. GROHN Olli TANILA Heikki MANGIA Silvia MICHAELI Shalom
Rok publikování	2020
Druh	Článek v odborném periodiku
Časopis / Zdroj	Neuroimage
Fakulta / Pracoviště MU	Lékařská fakulta
Citace
www	https://www.sciencedirect.com/science/article/pii/S1053811920302378?via%3Dihub
Doi	http://dx.doi.org/10.1016/j.neuroimage.2020.116750
Klíčová slova	Deep brain stimulation; Subthalamic nucleus; fMRI; Orientation selective; Parkinson's disease; Movement disorders
Popis	Deep brain stimulation (DBS) has become an important tool in the management of a wide spectrum of diseases in neurology and psychiatry. Target selection is a vital aspect of DBS so that only the desired areas are stimulated. Segmented leads and current steering have been shown to be promising additions to DBS technology enabling better control of the stimulating electric field. Recently introduced orientation selective DBS (OS-DBS) is a related development permitting sensitization of the stimulus to axonal pathways with different orientations by freely controlling the primary direction of the electric field using multiple contacts. Here, we used OS-DBS to stimulate the subthalamic nucleus (STN) in healthy rats while simultaneously monitoring the induced brain activity with fMRI. Maximal activation of the sensorimotor and basal ganglia-thalamocortical networks was observed when the electric field was aligned mediolaterally in the STN pointing in the lateral direction, while no cortical activation was observed with the electric field pointing medially to the opposite direction. Such findings are consistent with mediolateral main direction of the STN fibers, as seen with high resolution diffusion imaging and histology. The asymmetry of the OS-DBS dipolar field distribution using three contacts along with the potential stimulation of the internal capsule, are also discussed. We conclude that OS-DBS offers an additional degree of flexibility for optimization of DBS of the STN which may enable a better treatment response.