Soluble triggering receptor expressed on myeloid cells‑1 is a marker of organ injuries in cardiogenic shock: results from the CardShock Study

• Autoři: KIMMOUN Antoine; DUARTE Kevin; HARJOLA Veli-Pekka; TARVASMAKI Tuukka; LEVY Bruno; MEBAZAA Alexandre; GIBOT Sebastien; KONIARI Katerina; VOUMVOURAKIS Astrinos; KARAVIDAS Apostolos; PARISSIS John; SANS-ROSELLO Jordi; VILA Montserrat; DURAN-CAMBRA Albert; SIONIS Alessandro; PARENICA Jiri; STIPAL Roman; LUDKA Ondřej
• Rok publikování: 2022
• Druh: Článek v odborném periodiku
• Časopis / Zdroj: Clinical Research in Cardiology
• Fakulta / Pracoviště MU: Lékařská fakulta
• www: https://link.springer.com/content/pdf/10.1007/s00392-021-01823-0.pdf
• Doi: http://dx.doi.org/10.1007/s00392-021-01823-0
• Klíčová slova: Biomarkers; STREM; Cardiogenic Shock; Outcome
• Popis: Optimal outcome after cardiogenic shock (CS) depends on a coordinated healing response in which both debris removal and extracellular matrix tissue repair play a crucial role. Excessive inflammation can perpetuate a vicious circle, positioning leucocytes as central protagonists and potential therapeutic targets. High levels of circulating Triggering Receptor Expressed on Myeloid cells-1 (TREM-1), were associated with death in acute myocardial infarction confirming excessive inflammation as determinant of bad outcome. The present study aims to describe the association of soluble TREM-1 with 90-day mortality and with various organ injuries in patients with CS.