Informace o publikaci
Actin and Cytokinesis in Fission Yeasts
| Autoři | |
|---|---|
| Rok publikování | 1999 |
| Druh | Článek ve sborníku |
| Konference | VII. Cytoskeletální klub |
| Fakulta / Pracoviště MU | |
| Citace | |
| Obor | Mikrobiologie, virologie |
| Klíčová slova | actin; cytokinesis; fission yeasts |
| Popis | F-actin occurs in several forms in yeasts:(i) hypothetically F-actin is a part of cytoskeletal subsystems of membrane cytoskeleton, (ii)microfilament cables are related to cell polarity, (iii) actin patches are at regions of surface growth, (iv) F-actin as a component of actin contractile ring realises cytokinesis. This report concentrates on the function of F-actin at cell division of fission yeasts. F-actin is essential, but not a single component of mechanism of cell division. Comparison of (i) actin mutant of S.pombe, incapable to aassemble actin cytoskeleton even at permissive temperature, and (ii) inhibition of actin polymerization by cytochalasin D in S.pombe and S. japonicus suggests that F-actin contractile ring is the main component ensuring the course of cytokinesis. While in actin mutant incapability of formation of actin cytoskeleton is followed by a complex of irreversible changes of cell functions and, consequently, also by incapability of cytokinesis, inhibition of F-actin polymerization enables to identify targets of consequences of incapability to polymerise new filament structures contractile ring including and to study reversibility of the processes blocked. Inhibition of actin polymerization by cytochalasins induces relatively reversible phenocopy modelling irreversible gene mutations. |
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