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The future for the application of fibroblast growth factor 2 in modern wound healing

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HOLOUBEK Jakub LIPOVÝ Břetislav KNOZ Martin KEMPNÝ Tomáš CHALOUPKOVÁ Radka DAMBORSKÝ Jiří VOJTOVÁ Lucy

Rok publikování 2023
Druh Článek v odborném periodiku
Časopis / Zdroj BURNS
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www https://www.sciencedirect.com/science/article/pii/S030541792200273X?via%3Dihub
Doi http://dx.doi.org/10.1016/j.burns.2022.10.007
Klíčová slova fibroblast growth factor 2; wound healing
Popis Representatives of the fibroblast growth factor (FGF) family regulate a wide range of biological functions important for every phase of wound healing, such as cell proliferation, migration, and differentiation. The name of the family is derived from the primary assumption that FGF proteins (FGF1 and FGF2) are important for promoting fibroblast migration and proliferation. Today, FGFs are known to intervene in a wide range of biological functions of various cell populations. Their function is mediated by binding to specific receptors (tyrosine-kinase receptors), which leads to their activation and transmembrane signal transduction into the cell.
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