Informace o publikaci

Lipoprotein Subfractions Associated with Endothelial Function in Previously Healthy Subjects with Newly Diagnosed Sleep Apnea-A Pilot Study

Autoři	HLUCHANOVA Alzbeta KOLLAR Branislav KLOBUCNIKOVA Katarina HARDONOVA Miroslava PODDANY Michal ZITNANOVA Ingrid DVORAKOVA Monika KONARIKOVA Katarina TEDLA Miroslav URÍK Milan KLAIL Pavel SKOPEK Petr TURCANI Peter SIARNIK Pavel
Rok publikování	2023
Druh	Článek v odborném periodiku
Časopis / Zdroj	LIFE-BASEL
Fakulta / Pracoviště MU	Lékařská fakulta
Citace
www	https://www.mdpi.com/2075-1729/13/2/441
Doi	http://dx.doi.org/10.3390/life13020441
Klíčová slova	lipoprotein subfractions; obstructive sleep apnea; polysomnography
Popis	Background: Obstructive sleep apnea (OSA) activates several pathophysiological mechanisms which can lead to the development of vascular diseases. Endothelial dysfunction (ED) is an initial step in the development of atherosclerosis. The association between ED and OSA has been described in several studies, even in previously healthy subjects. High-density lipoproteins (HDL) were generally considered to be atheroprotective, and low-density lipoprotein (LDL) to be an atherogenic component of lipoproteins. However, recent findings suggest a pro-atherogenic role of small HDL subfractions (8-10) and LDL subfractions (3-7). This study aimed to evaluate the relationship between endothelial function and lipid subfractions in previously healthy OSA subjects. Material and Methods: We prospectively enrolled 205 subjects with sleep monitoring. Plasma levels of triacylglycerols, total cholesterol, LDL, HDL, and their subfractions were assessed. Endothelial function was determined using peripheral arterial tonometry, and reperfusion hyperemia index (RHI) was assessed. Results: Plasma levels of small and intermediate HDL subfractions have statistically significant pro-atherogenic correlations with endothelial function (p = 0.015 and p = 0.019). In other lipoprotein levels, no other significant correlation was found with RHI. In stepwise multiple linear regression analysis, small HDL (beta = -0.507, p = 0.032) was the only significant contributor in the model predicting RHI. Conclusions: In our studied sample, a pro-atherogenic role of small HDL subfractions in previously healthy subjects with moderate-to-severe OSA was proven.