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Plasma-Derived Nanoclusters for Site-Specific Multimodality Photo/Magnetic Thrombus Theranostics

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LIU Chia-Hung LIU Ming-Che JHENG Pei-Ru YU Jiashing FAN Yu-Jui LIANG Jia-Wei HSIAO Yu-Cheng CHIANG Chih-Wei BOLOUKI Nima LEE Jyh-Wei HSIEH Jang-Hsing MANSEL Bradley W. CHEN Yan-Ting NGUYEN Hieu Trung CHUANG Er-Yuan

Rok publikování 2023
Druh Článek v odborném periodiku
Časopis / Zdroj Advanced Healthcare Materials
Fakulta / Pracoviště MU

Přírodovědecká fakulta

Citace
www https://doi.org/10.1002/adhm.202301504
Doi http://dx.doi.org/10.1002/adhm.202301504
Klíčová slova biomarkers; cold atmospheric plasma; multimodal theranostic; nanoclusters; photo; magnetic thrombolysis
Popis Traditional thrombolytic therapeutics for vascular blockage are affected by their limited penetration into thrombi, associated off-target side effects, and low bioavailability, leading to insufficient thrombolytic efficacy. It is hypothesized that these limitations can be overcome by the precisely controlled and targeted delivery of thrombolytic therapeutics. A theranostic platform is developed that is biocompatible, fluorescent, magnetic, and well-characterized, with multiple targeting modes. This multimodal theranostic system can be remotely visualized and magnetically guided toward thrombi, noninvasively irradiated by near-infrared (NIR) phototherapies, and remotely activated by actuated magnets for additional mechanical therapy. Magnetic guidance can also improve the penetration of nanomedicines into thrombi. In a mouse model of thrombosis, the thrombosis residues are reduced by & AP;80% and with no risk of side effects or of secondary embolization. This strategy not only enables the progression of thrombolysis but also accelerates the lysis rate, thereby facilitating its prospective use in time-critical thrombolytic treatment.

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