Informace o publikaci

Acute generalized exanthematous pustulosis: European expert consensus for diagnosis and management

Autoři	TETART F. WALSH S. MILPIED B. GASPAR K. VOROBYEV A. TIPLICA G.S. DIDONA B. WELFRINGER-MORIN A. KUCINSKIENE V. BENSAID B. MARVANOVÁ Edita SALAVASTRU C. BŘEZINOVÁ Eva CHUA S.L. LOVGREN M.L. HAMMERS C.M. BARBAUD A. MORTZ C.G. HORVATH B. MEYERSBURG D. LEBRUN-VIGNES B. BODEMER C. BRÜGGEN M.C. FRENCH L.E. INGEN-HOUSZ-ORO S.
Rok publikování	2024
Druh	Článek v odborném periodiku
Časopis / Zdroj	JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
Fakulta / Pracoviště MU	Lékařská fakulta
Citace
www	https://doi.org/10.1111/jdv.20232
Doi	http://dx.doi.org/10.1111/jdv.20232
Klíčová slova	Acute generalized exanthematous pustulosis
Popis	Acute generalized exanthematous pustulosis (AGEP) is a rare, usually drug-induced, acute pustular rash. Despite the lack of strong data supporting the effectiveness of topical or systemic corticosteroids in this drug reaction, they are widely used. More generally, there is no consensus on the diagnostic modalities and the management of patients with AGEP. We aimed to provide European expert recommendations for the diagnosis and management or patients with AGEP. Members of the ToxiTEN group of the European Reference Network (ERN)-skin, all dermatologists and/or allergologists with expertise in drug reactions, elaborated these recommendations based on their own experience and on a review of the literature. Recommendations were separated into the following categories: professionals involved, assessment of the diagnosis of AGEP, management of the patient and allergological work-up after the acute phase. Consensus was obtained among experts for the list of professionals involved for the diagnosis and management of AGEP, including the minimum diagnostic work-up, the setting of management, the treatments, the modalities and the timing of allergological work-up and follow-up. European experts in drug allergies propose herein consensus on the diagnosis and management of patients with AGEP. A multidisciplinary approach is warranted, including dermatologists, allergologists and pharmacovigilance services.