Informace o publikaci

NeuroRoots, a bio-inspired, seamless brain machine interface for long-term recording in delicate brain regions

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FERRO Marc D PROCTOR Christopher M GONZALEZ Alexander JAYABAL Sriram ZHAO Eric GAGNON Maxwell SLEZIA Andrea PAS Jolien DIJK Gerwin DONAHUE Mary J WILLIAMSON Adam RAYMOND Jennifer MALLIARAS George G GIOCOMO Lisa MELOSH Nicholas A

Rok publikování 2024
Druh Článek v odborném periodiku
Časopis / Zdroj AIP Advances
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www https://pubs.aip.org/aip/adv/article/14/8/085109/3307242/NeuroRoots-a-bio-inspired-seamless-brain-machine
Doi http://dx.doi.org/10.1063/5.0216979
Klíčová slova NeuroRoots; brain machine interface; delicate brain regions
Popis Scalable electronic brain implants with long-term stability and low biological perturbation are crucial technologies for high-quality brain-machine interfaces that can seamlessly access delicate and hard-to-reach regions of the brain. Here, we created "NeuroRoots," a biomimetic multi-channel implant with similar dimensions (7 mu m wide and 1.5 mu m thick), mechanical compliance, and spatial distribution as axons in the brain. Unlike planar shank implants, these devices consist of a number of individual electrode "roots," each tendril independent from the other. A simple microscale delivery approach based on commercially available apparatus minimally perturbs existing neural architectures during surgery. NeuroRoots enables high density single unit recording from the cerebellum in vitro and in vivo. NeuroRoots also reliably recorded action potentials in various brain regions for at least 7 weeks during behavioral experiments in freely-moving rats, without adjustment of electrode position. This minimally invasive axon-like implant design is an important step toward improving the integration and stability of brain-machine interfacing.

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