Informace o publikaci

Impact of PD-L1 Expression on the Overall Survival of Patients With Non-small Cell Lung Cancer Treated With Single-agent Pembrolizumab

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SVATON Martin KNETKI-WROBLEWSKA Magdalena TABOR Sylwia DOMECKY Petr VENCLÍČEK Ondřej KREJCI Jana DROSSLEROVA Marie HRNCIARIK Michal HRICISAK Daniel BEJCKOVA Alzbeta FISCHER Ondrej VITKOVA Martina KRZAKOWSKI Maciej

Rok publikování 2024
Druh Článek v odborném periodiku
Časopis / Zdroj In vivo
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www https://iv.iiarjournals.org/content/38/5/2434
Doi http://dx.doi.org/10.21873/invivo.13712
Klíčová slova Non-small cell lung cancer; pembrolizumab; overall survival; PD-L1 expression
Popis Background/Aim: Cemiplimab in patients with non-small cell lung cancer (NSCLC) with PD-L1 (programmed death ligand type 1) expression >= 50% showed a significant improved overall survival (OS) with increasing expression of PD-L1. To our knowledge there exist no similar data published for pembrolizumab regarding the increased OS in relation to the PD-L1 expression. Therefore, the objective of our study was to determine whether improvement in OS reflects increased expression levels of PD-L1 (>= 50%) >= 50%) in patients with NSCLC. Patients and Methods: Retrospective data from 9 Czech and 1 Polish comprehensive oncology Centers were used. All patients with stage IV NSCLC and PD-L1 expression >= 50% treated with pembrolizumab in daily practice were included. The groups of patients according to the expression of PD-L1 were determined as follows: PD-L1 50-59%, 60-69%, 70-79%, 80-89% and 90-100%. The log-rank test and the Cox regression model were used to compare survival between study groups. Results: A total of 617 patients were included in the study. We did not observe a statistically significant difference in OS between groups of patients with different levels of PD-L1 expression in the pooled comparison (p=0.445). Furthermore, we did not observe a statistically significant difference even when comparing OS in patients with PD-L1expression of 50-59% (reference) with the group of other patients according to the level of expression of PD- L1 in the Cox regression model including the effect covariates. Conclusion: PD-L1 expression showed no significant effect on OS in patients with NSCLC with PD- L1 >= 50% >= 50% treated with pembrolizumab.

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