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Enantiomeric analysis of (3S,4R)-4-(4-fluorophenyl)-3-hydroxymethyl-1-methylpiperidine by 19F NMR spectroscopy

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NAVRÁTILOVÁ Hana

Rok publikování 2001
Druh Článek v odborném periodiku
Časopis / Zdroj Magnetic Resonance in Chemistry
Fakulta / Pracoviště MU

Fakulta informatiky

Citace
Obor Organická chemie
Klíčová slova NMR; 13C satellites; chemical-shift anisochrony; piperidines; paroxetine;
Popis The chemical shift anisochrony of the fluorine signal for the enantiomerically enriched (3S,4R)-4-(4-fluorophenyl)-3-hydroxymethyl-1-methylpiperidine was induced in the presence of S-Mosher acid and its magnitude varied with the enantiomeric purity of 1a. Very low quantities of an enantiomeric impurity 1b, ranging typically from 0.2 to 1%, were evaluated by comparing peak areas of 1b with those of 13C satellite signals that were deconvoluted using an automatic Lorentzian line fitting.
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