![Důležité termíny](https://cdn.muni.cz/media/3633704/image_2.jpg?mode=crop¢er=0.5,0.5&rnd=133572412150000000&heightratio=0.5&width=278)
Informace o publikaci
Changes of IL-6 protein and its receptor GP130 in the rat dorsal root ganglia after spinal nerve ligature.
Název česky | Změny IL-6 a jeho receptoru ve spinálních gangliích potkana po ligatuře spinálního nervu. |
---|---|
Autoři | |
Rok publikování | 2008 |
Druh | Další prezentace na konferencích |
Fakulta / Pracoviště MU | |
Citace | |
Popis | Robust axon regeneration and neuropathic pain induction occurs after peripheral nerve injury through coordinated activation of a genetic program and local intracellular signaling cascades. Although regeneration-associated genes are being identified with increasing frequency, most aspects of regeneration-associated intracellular signaling remain poorly understood. The sciatic nerve injury induces up-regulation of IL-6. We were used ligature of spinal nerves for investigation of temporal changes of IL-6 protein and its receptor gp130 in both ipsi- and contralateral lumbal (L4-L5) dorsal root ganglia. The obtained data provide evidence for changes of IL-6 protein levels not only in dorsal root ganglia's associated with damaged nerve, but also in those non-associated with nerve injury in the rat experimental neuropathic pain model. |
Související projekty: |