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Paliperidon mediated modification of cortical inhibition

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PŘIKRYL Radovan USTOHAL Libor PŘIKRYLOVÁ KUČEROVÁ Hana ČEŠKOVÁ Eva

Rok publikování 2009
Druh Článek v odborném periodiku
Časopis / Zdroj Neuroendocrinology Letters
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Obor Psychiatrie, sexuologie
Klíčová slova cortical silent period; first episode; GABA; paliperidon; transcranial magnetic stimulation; schizophrenia
Popis Transcranial magnetic stimulation is a neurophysiological method which enables direct quantitative in vivo assessment of cortical excitability and inhibition. The aim of the study was to assess the impact of paliperidone on the motor threshold and cortical silent period, in a drug-naive patient, with first episode schizophrenia using this technique. Paliperidone monotherapy caused a significant reduction of severity of schizophrenic symptomatology in the patient. At the same time, a significant prolongation of the cortical silent period, from 118.68 ms before to 185.13 ms after therapy, occurred. Because the cortical silent period is a function of GABAB receptors, we can assume that paliperidone may have the ability to enhance GABAB receptor-mediated neurotransmission.
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