PhD Candidate/Student in regulation of translation

Come to CEITEC MU in Brno and join us!

We are passionate structural biologists at CEITEC looking for 

PhD Candidate/Student in regulation of translation

About this position: 

We're excited to announce an open PhD student position in Gabriel Demo's Research Group!

Understanding the intricate mechanisms regulating ribosome maturation and translation under extreme or stress-induced conditions is vital for uncovering how cells adapt to challenging environments. This project will focus on investigating the molecular mechanisms behind ribosome maturation in bacteria and translation regulation in archaea under such conditions. The ultimate goal is to reveal the adaptation strategies that enable cell survival.

By employing state-of-the-art single-particle cryo-electron microscopy (cryo-EM), the project will provide high-resolution structural insights into ribosomal assembly intermediates, stress-induced translation factors, and archaeal translation machinery under extreme conditions. This research is anticipated to significantly advance our understanding of cellular translation regulation and its role in stress and survival mechanisms.

The research will involve close collaboration with leading experimental teams and will be tailored to the interests and strengths of the candidate. We look forward to discussing this exciting opportunity and the project's scope further during the interview.

The ideal candidate profile: 

Must-have: 

• MSc or equivalent degree in biochemistry or structural biology and related fields 
• Practical experience working in the wet lab, mainly focusing on translation (purification of ribosomes, ribosome complex assembly, etc.)
• Theoretical knowledge of single parcticle cryo-electron microscopy
• Good English language – spoken and written

Nice-to-have:   

• Work experience in cryo-electron microscopy and data analysis
• Good communication and interpersonal skills
• Motivation and a collaborative mindset

What we provide to you: 

• Open access to CEITEC MU core facilities with state-of-the-art equipment and experienced staff
• Full-time contract
• An attractive salary 
• Flexible working hours
• Support for further education and professional development 
• Benefits package: 6 weeks of paid holiday, medical insurance, financial contribution to meal and kindergarten/pension scheme, Multisport card, mental health care, sports lessons directly at the campus 
• Kindergarten Elánek in Campus
• Support in these areas:
  • Welcome Office service before and after arrival 
  • Grant Office support 
  • Postdoc Peer Committee  
  • CEITEC events – workshops, conferences, lectures, training, family gathering etc. 

How to apply? 

Application deadline: 19.01.2025

Start date: September 2025 (by negotiation – based on autumn semester start date)

Applications, including a CV, motivation letter, list of publications, and contacts for at least two references should be sent an e-application. 

Any troubles with the e-application, please contact Petra Linhartova (petra.linhartova@ceitec.muni.cz)