Mgr. Michaela Bosáková, Ph.D.

2017

• ARQ 087 inhibits FGFR signaling and rescues aberrant cell proliferation and differentiation in experimental models of craniosynostoses and chondrodysplasias caused by activating mutations in FGFR1, FGFR2 and FGFR3

  BÁLEK Lukáš GUDERNOVÁ Iva VESELA Iva HAMPL Marek ORALOVÁ Veronika BOSÁKOVÁ Michaela VAŘECHA Miroslav NĚMEC Pavel HALL Terence ABBADESSA Giovanni HATCH Nan BUCHTOVÁ marcela KREJČÍ Pavel

  Article in Periodical

  Bone, year: 2017, volume: 105, edition: DEC 2017, DOI

• Inhibitor repurposing reveals ALK, LTK, FGFR, RET and TRK kinases as the targets of AZD1480

  GUDERNOVÁ Iva BÁLEK Lukáš VAŘECHA Miroslav FIALOVÁ KUČEROVÁ Jana BOSÁKOVÁ Michaela FAFÍLEK Bohumil PALUŠOVÁ Veronika ULDRIJAN Stjepan TRANTÍREK Lukáš KREJČÍ Pavel

  Article in Periodical

  Oncotarget, year: 2017, volume: 8, edition: 65, DOI

• One reporter for in-cell activity profiling of majority of protein kinase oncogenes

  GUDERNOVÁ Iva TRANTÍRKOVÁ Silvie EL GHANNAMOVÁ Barbora FAFÍLEK Bohumil VAŘECHA Miroslav BÁLEK Lukáš HRUBÁ Eva JONÁTOVÁ Lucie JELÍNKOVÁ Iva BOSÁKOVÁ Michaela TRANTÍREK Lukáš MAYER Jiří KREJČÍ Pavel

  Article in Periodical

  eLife, year: 2017, volume: 6, edition: "e21536", DOI

• Properties of Human Embryonic Stem Cells and Their Differentiated Derivatives Depend on Nonhistone DNA-Binding HMGB1 and HMGB2 Proteins

  BAGHERPOOR Alireza Jian DOLEŽALOVÁ Dáša BÁRTA Tomáš KUČÍREK Martin SANI Soodabeh Abbasi EŠNER Milan BOSÁKOVÁ Michaela VINARSKÝ Vladimír PEŠKOVÁ Lucie HAMPL Aleš ŠTROS Michal

  Article in Periodical

  Stem Cells and Development, year: 2017, volume: 26, edition: 5, DOI

• Role of Primary Cilia in Odontogenesis

  HAMPL Marek CELA P. SZABO-ROGERS H.L. BOSÁKOVÁ Michaela DOSEDELOVA H. KREJČÍ Pavel BUCHTOVÁ marcela

  Article in Periodical

  Journal of Dental Research, year: 2017, volume: 96, edition: 9, DOI

• Statins do not inhibit the FGFR signaling in chondrocytes

  FAFÍLEK Bohumil HAMPL Marek ŘIČÁNKOVÁ Nikola VESELA I. BÁLEK Lukáš BOSÁKOVÁ Michaela GUDERNOVÁ Iva VAŘECHA Miroslav BUCHTOVÁ marcela KREJČÍ Pavel

  Article in Periodical

  Osteoarthritis and Cartilage, year: 2017, volume: 25, edition: 9, DOI

• Tyrosine Kinase Expressed in Hepatocellular Carcinoma, TEC, Controls Pluripotency and Early Cell Fate Decisions of Human Pluripotent Stem Cells via Regulation of Fibroblast Growth Factor-2 Secretion

  VÁŇOVÁ Tereza KONEČNÁ Žaneta ZBOŇÁKOVÁ Zuzana LA VENUTA Giuseppe ZOUFALOVÁ Karolína JELÍNKOVÁ Šárka VAŘECHA Miroslav ROTREKL Vladimír KREJČÍ Pavel NICKEL Walter DVOŘÁK Petr BOSÁKOVÁ Michaela

  Article in Periodical

  Stem Cells, year: 2017, volume: 35, edition: 9, DOI

2016

• An inactivating mutation in intestinal cell kinase, ICK, impairs hedgehog signalling and causes short rib-polydactyly syndrome

  TAYLOR S. Paige BOSÁKOVÁ Michaela VAŘECHA Miroslav BÁLEK Lukáš BÁRTA Tomáš TRANTÍREK Lukáš JELÍNKOVÁ Iva DURAN Ivan VESELÁ Iva FORLENZA Kimberly N. MARTIN Jorge H. HAMPL Aleš BAMSHAD Michael NICKERSON Deborah JAWORSKI Margie L. SONG Jieun WAN KO Hyuk COHN Daniel H. KRAKOW Deborah KREJČÍ Pavel

  Article in Periodical

  Human Molecular Genetics, year: 2016, volume: 25, edition: 18, DOI

• MORN5 Expression during Craniofacial Development and Its Interaction with the BMP and TGF beta Pathways

  CELÁ Petra HAMPL Marek FU Katherine K. BOSÁKOVÁ Michaela KREJČÍ Pavel RICHMAN Joy M. BUCHTOVÁ marcela

  Article in Periodical

  Frontiers in Physiology, year: 2016, volume: 7, edition: August, DOI

• Multikinase activity of fibroblast growth factor receptor (FGFR) inhibitors SU5402, PD173074, AZD1480, AZD4547 and BGJ398 compromises the use of small chemicals targeting FGFR catalytic activity for therapy of short stature syndromes

  GUDERNOVÁ Iva VESELA Iva BÁLEK Lukáš BUCHTOVÁ marcela DOSEDELOVA Hana KUNOVÁ Michaela PIVNIČKA Jakub JELÍNKOVÁ Iva ROUBALOVA Lucie KOZUBÍK Alois KREJČÍ Pavel

  Article in Periodical

  Human Molecular Genetics, year: 2016, volume: 25, edition: 1, DOI