RNDr. Mário Špírek, PhD.

2024

• Mechanism of BCDX2-mediated RAD51 nucleation on short ssDNA stretches and fork DNA

  AKITA Masaki GIRVAN Paul ŠPÍREK Mário NOVÁČEK Jiří RUEDA David PROKOP Zbyněk KREJČÍ Lumír

  Article in Periodical

  Nucleic acids research, year: 2024, DOI

• Physical interaction with Spo11 mediates the localisation of Mre11 to chromatin in meiosis and promotes its nuclease activity

  AITHAL Rakesh NANGALIA Kuldeep ŠPÍREK Mário CHEN Doris KLEIN Franz KREJČÍ Lumír

  Article in Periodical

  Nucleic acids research, year: 2024, volume: 52, edition: 8, DOI

2022

• The role of bivalent ions in the regulation of D-loop extension mediated by DMC1 during meiotic recombination

  ALTMANNOVÁ Veronika ŠPÍREK Mário ORLIC Lucija JEKABSONS Atis CLARENCE Tereza HENGGELER Adrian MLCOUSKOVA Jarmila CHALEIL Raphael A G MATOS Joao KREJČÍ Lumír

  Article in Periodical

  iSCIENCE, year: 2022, volume: 25, edition: 11, DOI

2021

• Nucleotide proofreading functions by nematode RAD51 paralogs facilitate optimal RAD51 filament function

  ŠPÍREK Mário TAYLOR M. R. G. BELÁŇ Ondrej BOULTON S. J. KREJČÍ Lumír

  Article in Periodical

  Nature Communications, year: 2021, volume: 12, edition: 1, DOI

• Single-molecule visualization of human RECQ5 interactions with single-stranded DNA recombination intermediates

  XUE C. Y. MOLNÁROVÁ Lucia STEINFELD J. B. ZHAO W. X. MA C. J. ŠPÍREK Mário KANIECKI K. KWON Y. BELAN Ondrej KREJČÍ Kateřina BOULTON S. J. SUNG P. GREENE E. C. KREJČÍ Lumír

  Article in Periodical

  Nucleic acids research, year: 2021, volume: 49, edition: 1, DOI

2020

• Antibiotic-induced DNA damage results in a controlled loss of pH homeostasis and genome instability

  BOOTH James Alexander ŠPÍREK Mário LOBIE Tekle Airgecho SKARSTAD Kirsten KREJČÍ Lumír BJORAS Magnar

  Article in Periodical

  Scientific reports, year: 2020, volume: 10, edition: 1, DOI

• DSS1 interacts with and stimulates RAD52 to promote the repair of DSBs

  ŠTEFANOVIE Barbora HENGEL Sarah R. MLČOUŠKOVÁ Jarmila PROCHAZKOVA Jana ŠPÍREK Mário NIKULENKOV Fedor NĚMEČEK Daniel KOCH Brandon G. BAIN Fletcher E. YU Liping SPIES Maria KREJČÍ Lumír

  Article in Periodical

  Nucleic Acids Research, year: 2020, volume: 48, edition: 2, DOI

• Mussel-mimicking sulfobetaine-based copolymer with metal tunable gelation, self-healing and antibacterial capability

  MRLIK M. ŠPÍREK Mário AL-KHORI J. AHMAD A. A. MOSNACEK J. ALMAADEED M. A. KASAK P.

  Article in Periodical

  Arabian Journal of Chemistry, year: 2020, volume: 13, edition: 1, DOI

2018

• Human RAD51 rapidly forms intrinsically dynamic nucleoprotein filaments modulated by nucleotide binding state

  ŠPÍREK Mário MLČOUŠKOVÁ Jarmila BELÁŇ Ondrej GYIMESI Máté HARAMI Gábor M. MOLNÁR Eszter NOVÁČEK Jiří KOVÁCS Mihály KREJČÍ Lumír

  Article in Periodical

  Nucleic Acids Research, year: 2018, volume: 46, edition: 8, DOI

2017

• Fanconi-Anemia-Associated Mutations Destabilize RAD51 Filaments and Impair Replication Fork Protection

  MOVSESJAN Karina SANNINO V. BELÁŇ Ondrej MLČOUŠKOVÁ Jarmila ŠPÍREK Mário COSTANZO V. KREJČÍ Lumír

  Article in Periodical

  Cell Reports, year: 2017, volume: 21, edition: 2, DOI