Liam Keegan, PhD.

2024

• Amyloid precursor protein induces reactive astrogliosis

  JAUREGUI Gretsen Velezmoro VUKIĆ Dragana ONYANGO Isaac G ARIAS Carlos NOVOTNY Jan S TEXLOVA Katerina WANG Shanshan KOVACOVICOVA Kristina Locker POLAKOVA Natalie ZELINKOVA Jana CARNA Maria LACOVICH STRAŠIL Valentina HEAD Brian P HAVAS Daniel MISTRIK Martin ZOREC Robert VERKHRATSKY Alexei KEEGAN Liam O'CONNELL Mary Anne RISSMAN Robert STOKIN Gorazd B

  Article in Periodical

  Acta Physiologica, year: 2024, volume: 240, edition: 6, DOI

• An ADAR1 dsRBD3-PKR kinase domain interaction on dsRNA inhibits PKR activation

  SINIGAGLIA Ketty CHERIAN Anna DU Qiupei LACOVICH STRAŠIL Valentina VUKIĆ Dragana MELICHEROVÁ Janka MUSILOVÁ Pavla ZERAD Lisa STEJSKAL Stanislav MALIK Radek PROCHAZKA Jan BONDURAND Nadege SEDLACEK Radislav O'CONNELL Mary Anne KEEGAN Liam

  Article in Periodical

  Cell Reports, year: 2024, volume: 43, edition: 8, DOI

2023

• Adenosine Deaminase Acting on RNA (ADAR) Enzymes: A Journey from Weird to Wondrous

  KEEGAN Liam HAJJI Khadija O'CONNELL Mary Anne

  Article in Periodical

  Accounts of chemical research, year: 2023, volume: 56, edition: 22, DOI

2022

• ADAR2 enzymes: efficient site-specific RNA editors with gene therapy aspirations

  HAJJI Khadija SEDMÍK Jiří CHERIAN Anna AMORUSO Damiano KEEGAN Liam O'CONNELL Mary Anne

  Article in Periodical

  RNA, year: 2022, volume: 28, edition: 10, DOI

2021

• ADAR RNA Modifications, the Epitranscriptome and Innate Immunity

  QUIN Jaclyn Elizabeth SEDMÍK Jiří VUKIĆ Dragana KHAN Anzer KEEGAN Liam O'CONNELL Mary Anne

  Article in Periodical

  Trends in Biochemical Sciences, year: 2021, volume: 46, edition: 9, DOI

• Biallelic variants in ADARB1, encoding a dsRNA-specific adenosine deaminase, cause a severe developmental and epileptic encephalopathy

  MAROOFIAN Reza SEDMÍK Jiří MAZAHERI Neda SCALA Marcello ZAKI Maha S. KEEGAN Liam AZIZIMALAMIRI Reza ISSA Mahmoud SHARIATI Gholamreza SEDAGHAT Alireza BEETZ Christian BAUER Peter GALEHDARI Hamid O'CONNELL Mary Anne HOULDEN Henry

  Article in Periodical

  Journal of Medical Genetics, year: 2021, volume: 58, edition: 7, DOI

• Interplays of different types of epitranscriptomic mRNA modifications

  RENGARAJ Praveenkumar OBRDLÍK Aleš VUKIĆ Dragana VARADARAJAN Nandan Mysore KEEGAN Liam VAŇÁČOVÁ Štěpánka O'CONNELL Mary Anne

  Article in Periodical

  RNA Biology, year: 2021, volume: 18, edition: S1, DOI

• The effects of RNA editing in cancer tissue at different stages in carcinogenesis

  KURKOWIAK M. ARCIMOWICZ L. CHRUSCIEL E. URBAN-WOJCIUK Z. PAPAK I. KEEGAN Liam O'CONNELL Mary Anne KOWALSKI J. HUPP T. MAREK-TRZONKOWSKA N.

  Article in Periodical

  RNA Biology, year: 2021, volume: 18, edition: 11, DOI

2020

• Adar RNA editing-dependent and -independent effects are required for brain and innate immune functions in Drosophila

  DENG Patricia KHAN Anzer JACOBSON Dionna SAMBRANI Nagraj MCGURK Leeanne LI Xianghua JAYASREE Aswathy HEJÁTKO Jan SHOHAT-OPHIR Galit O'CONNELL Mary Anne LI Jin Billy KEEGAN Liam

  Article in Periodical

  Nature Communications, year: 2020, volume: 11, edition: 1, DOI

• Bi-allelic ADARB1 Variants Associated with Microcephaly, Intellectual Disability, and Seizures

  TAN Tiong Yang SEDMÍK Jiří FITZGERALD Mark P. SUKENIK HALEVY Rivka KEEGAN Liam HELBIG Ingo BASEL-SALMON Lina COHEN Lior STRAUSSBERG Rachel CHUNG Wendy K. HELAL Mayada MAROOFIAN Reza HOULDEN Henry JUUSOLA Jane SADEDIN Simon PAIS Lynn HOWELL Katherine B. WHITE Susan M. CHRISTODOULOU John O'CONNELL Mary Anne

  Article in Periodical

  The American Journal of Human Genetics, year: 2020, volume: 106, edition: 4, DOI