RNDr. Ludmila Šebejová, Ph.D.

2013

• Reaktivace vybraných p53 mutantů u B-buněčných nádorových linií prostřednictvím malých cílených molekul

  JAŠKOVÁ Zuzana ŠEBEJOVÁ Ludmila POSPÍŠILOVÁ Šárka TRBUŠEK Martin

  Conference abstract

  Year: 2013, type: Conference abstract

• SF3B1 mutations frequently occur with both ATM mutations and TP53 mutations in CLL patients

  NAVRKALOVÁ Veronika MALČÍKOVÁ Jitka KANTOROVÁ Barbara ŠEBEJOVÁ Ludmila PLEVOVÁ Karla MRÁZ Marek DOUBEK Michael BRYCHTOVÁ Yvona ŠMARDOVÁ Jana MAYER Jiří POSPÍŠILOVÁ Šárka TRBUŠEK Martin

  Conference abstract

  Year: 2013, type: Conference abstract

• Synthetic lethality in p53 mutated B-cell mylignancies: Chk-1 inhibition and DNA-PK inhibition effect in cell lines and primary CLL cells

  ZEMANOVÁ Jana ŠEBEJOVÁ Ludmila PARUCH Kamil HYLSE Ondřej POSPÍŠILOVÁ Šárka MAYER Jiří TRBUŠEK Martin

  Conference abstract

  Year: 2013, type: Conference abstract

• The BCR-ABL1 T315I mutation and additional genomic aberrations are dominant genetic lesions associated with disease progression in patients with chronic myelogenous leukemia resistant to tyrosine kinase inhibitor therapy.

  MALČÍKOVÁ Jitka RÁZGA Filip JURČEK Tomáš DVOŘÁKOVÁ Dana ŽÁČKOVÁ Daniela TOŠKOVÁ Hana ŠEBEJOVÁ Ludmila ŠMARDOVÁ Jana OLTOVÁ Alexandra VAŇKOVÁ Gabriela JURAČKOVÁ Lenka TRBUŠEK Martin POSPÍŠILOVÁ Šárka MAYER Jiří RÁČIL Zdeněk

  Article in Periodical

  Leukemia & Lymphoma, year: 2013, volume: 54, edition: 9, DOI

• The p53 pathway induction is not primarily dependent on Ataxia Telangiectasia Mutated (ATM) gene activity after fludarabine treatment in chronic lymphocytic leukemia cells

  NAVRKALOVÁ Veronika ŠEBEJOVÁ Ludmila ZEMANOVÁ Jana JAŠKOVÁ Zuzana TRBUŠEK Martin

  Article in Periodical

  Leukemia & Lymphoma, year: 2013, volume: 54, edition: 8, DOI

• TP53 mutations associate with higher in vitro resistance of CLL cells to ofatumumab and rituximab

  ŠEBEJOVÁ Ludmila ŠRÁMEK Martin JAŠKOVÁ Zuzana BORSKÝ Marek POTĚŠIL David NAVRKALOVÁ Veronika MALČÍKOVÁ Jitka BRYCHTOVÁ Yvona DOUBEK Michael MAYER Jiří POSPÍŠILOVÁ Šárka TRBUŠEK Martin

  Conference abstract

  Year: 2013, type: Conference abstract

• TP53 mutations but not ATM mutations associate with higher in vitro resistance of CLL cells to rituximab

  ŠEBEJOVÁ Ludmila ŠRÁMEK Martin JAŠKOVÁ Zuzana MALČÍKOVÁ Jitka NAVRKALOVÁ Veronika BORSKÝ Marek DOUBEK Michael MAYER Jiří POSPÍŠILOVÁ Šárka TRBUŠEK Martin

  Conference abstract

  Year: 2013, type: Conference abstract

2012

• Analýza mutací v genech pro mikroRNA u pacientů s chronickou lymfocytární leukémií.

  KMÍNKOVÁ Jana MRÁZ Marek NAVRKALOVÁ Veronika PAVLOVÁ Šárka PLEVOVÁ Karla TICHÝ Boris MALČÍKOVÁ Jitka ŠEBEJOVÁ Ludmila BENEŠ Vladimír RAUSCH T. BRYCHTOVÁ Yvona DOUBEK Michael TRBUŠEK Martin MAYER Jiří POSPÍŠILOVÁ Šárka

  Conference abstract

  Year: 2012, type: Conference abstract

• Deep sequencing identifies TP53 mutations before their clonal selection by therapy in chronic lymphocytic leukemia

  TRBUŠEK Martin STAŇO KOZUBÍK Kateřina MALČÍKOVÁ Jitka ŠMARDOVÁ Jana ŠEBEJOVÁ Ludmila DOUBEK Michael BRYCHTOVÁ Yvona SVITÁKOVÁ M. PAVLOVÁ Šárka MRÁZ Marek PLEVOVÁ Karla VRÁNOVÁ V. TOM Nikola MAYER Jiří POSPÍŠILOVÁ Šárka TICHÝ Boris

  Conference abstract

  Year: 2012, type: Conference abstract

• Defects of ATM gene involving mutation lead to complete elimination of ATM function in chronic lymphocytic leukemia

  NAVRKALOVÁ Veronika ZEMANOVÁ Jana ŠEBEJOVÁ Ludmila KMÍNKOVÁ Jana KUBEŠOVÁ Blanka DOUBEK Michael BRYCHTOVÁ Yvona MAYER Jiří POSPÍŠILOVÁ Šárka TRBUŠEK Martin

  Year: 2012, type: