Project information
Enhancement of G-CSF action by adenosine signalling: testing of its potential clinical use in murine models
- Project Identification
- GA306/99/0027
- Project Period
- 1/1999 - 1/2001
- Investor / Pogramme / Project type
-
Czech Science Foundation
- Standard Projects
- MU Faculty or unit
- Faculty of Medicine
- Cooperating Organization
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Institute of Biophysics
- Responsible person doc. MUDr. Michal Hofer, CSc.
Previous original findings of the applicants have demonstrated synergistic effects of granulocyte colony-stimulating factor (G-CSF) and drugs elevating extracellular adenosine (dipyridamole, AMP). Potentiation of proliferation and differentiation in the granulopoietic compartment has been shown in experiments on both normal and gamma-irradiated mice. The project submitted intends to extend these findings with respect to the clinical use of G-CSF. Interactions of G-CSF with dipyridamole and AMP will be s tudied in the following two experimental situations: (1) the use of G-CSF for stimulation of granulocyte production in neutropenic states evoked by cytotoxic drugs and (2) the use of G-CSF for mobilization of circulating hematopoietic progenitor cells.
Publications
Total number of publications: 6
2002
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Drugs elevating extracellular adenosine promote regeneration of haematopoietic progenitor cells in severely myeloosuppressed mice: their comparison and joint effects with the granulocyte colony-stimulating factor
European Journal of Haematology, year: 2002, volume: 68, edition: 1
2001
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Combination of drugs elevating extracellular adenosine with granulocyte colony-stimulating factor promotes granulopoietic recovery in the murine bone marrow after 5-fluorouracil treatment
Physiological Research, year: 2001, volume: 50, edition: March
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Drugs elevating extracellular adenosine enhance cell cycling of hematopoietic progenitor cells as inferred from the cytotoxic effects of 5-fluorouracil
Experimental Hematology, year: 2001, volume: 29, edition: 5
2000
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Influence of the joint treatment with granulocyte colony-stimulating factor and drugs elevating extracellular adenosine on erythropoietic recovery following 5-fluorouracil-induced haematotoxicity in mice
European Journal of Haematology, year: 2000, volume: 65, edition: 5
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Mutually potentiating effects of drugs elevating extracellular adenosine and granulocyte colony-stimulating factor on erythropoietic recovery following 5-fluorouracil-induced haematotoxicity in mice
Drug Development Research, year: 2000, volume: 50, edition: 1
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Radioprotective action of extracellular adenosine on bone marrow cells in mice exposed to gamma rays as assayed by the micronucleus test
Radiation Research, year: 2000, volume: 154, edition: 3