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Project information
Human genome structure

Project Identification
IAA5004306
Project Period
1/2003 - 12/2007
Investor / Pogramme / Project type
Academy of Sciences of the Czech Republic
  • Grants of distinctly investigative character focused on the sphere of research pursued at present particularly in the ASCR
MU Faculty or unit
Faculty of Informatics
Keywords
nuclear architecture; chromosome structure; FISH; high-resolution cytometry;
Cooperating Organization
Institute of Biophysics
  • Responsible person doc. RNDr. Stanislav Kozubek, DrSc.

One of the main directions of human genome research in the post-genomic eta is the study of its higher-order structure that became the key to understanding of the most important cellular processes such as cell differentiation or transformation. Using high-resolution cytometry developed in our laboratory, nuclear and territorial topography of genetic elements will be systematically investigated in normal and malignant human cell types. The topography and its changel will be correlated with local acetylation of histones, methylation of DNA and expression of gene clusters. In addition, changes of the structure of chromosome terriories or whole human genome in the cell nucleus during differentiation and cancerogenesis will be determined and an attempt will be made to find the basic psrinciples of the epigenetic regulation of gene expression. The practical goal of the project is the use of experimental results and technology developed in our laboratory in diagnostics ant therapy of cancer.

Results

The practical goal of the project is the use of experimental results and technology developed in our laboratory in diagnostics and therapy of cancer.

Publications

Total number of publications: 32

2009

2006

2005

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