Project information
Prdm9 - linking the histone modifications and recombination
(PLHMR)
- Project Identification
- 2SGA2773
- Project Period
- 8/2011 - 7/2013
- Investor / Pogramme / Project type
-
South-Moravian Region
- SoMoPro
- Incoming grants
- MU Faculty or unit
-
Faculty of Science
- doc. Mgr. Lumír Krejčí, Ph.D.
- Dr. Emil Damyanov Parvanov
Meiotic homologous recombination is a process common to all eukaryotes, which assures proper
segregation of homologous chromosomes in meiosis and provides genetic diversity by creating new
allelic combinations in every generation. In humans and other mammals the recombination events are
localized in tightly defined 1-2kb genomic regions (hotspots), irregularly spaced along the genome and
vary greatly in their activity. The major protein players in recombination are well studied, uncovering
the recombination on molecular level. Less is known about the factors defining the location of
recombination hotspots. Recent research in the group of Dr. K. Paigen (The Jackson Lab) shows that the
presence of CAST alleles of histone methyl-transferase Prdm9 on Chr17 can either activate or suppress
the activity of four individual hotspots on mouse Chr 1. Study of another group on Psmb1 hotspot
proved trans-regulation by factor mapped to the same region on Chr 17, at the region of Prdm9.
Publications
Total number of publications: 2
2017
-
PRDM9 interactions with other proteins provide a link between recombination hotspots and the chromosomal axis in meiosis
Molecular Biology of the Cell, year: 2017, volume: 28, edition: 3, DOI
2013
-
DNA binding specificities of the long zinc-finger recombination protein PRDM9
Genome Biology, year: 2013, volume: 14, edition: 4, DOI