Project information
Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies
- Project Identification
- MSM0021622430
- Project Period
- 1/2007 - 12/2013
- Investor / Pogramme / Project type
-
Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Faculty of Medicine
- Other MU Faculty/Unit
- Faculty of Science
- Other MU Faculty/Unit
- Faculty of Informatics
- Other MU Faculty/Unit
- Central European Institute of Technology
- Keywords
- embryonic stem cells
The goal of this project will be a) to profit from availability of unique cellular resources - mouse and human embryonic stem cells and normal and malignant hematopoietic stem/progenitor cells, b) to effectively employ a wide variety of current and complementary methodologies available to the consortium, and c) to exploit a proven/certified expertise in working with various living systems that span from in vitro cultured cells, through animal models to oncohematological patients. All this together will represent a powerful experimental platform aimed at addressing a nature of molecules and molecular mechanisms underlaying phenomena that are common to both normal and cancer stem cells, mainly their ability to self-renew and to enter differentiation pathways. Integral part of this general goal is to implement multifaceted analytical approach that will cover studies of gene expression at both mRNA and protein levels, evaluating function of extra and intracellular signaling pathways, and analyzing biological properties of cells in vitro and in vivo. Expected outcome will be not only understanding but also a definition of molecules and/or molecular pathways to be tested as therapeutic targets, and cellular models that will make such testing feasible.
Publications
Total number of publications: 358
2017
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Phenotypic assays for analyses of pluripotent stem cell-derived cardiomyocytes
Journal of Molecular Recognition, year: 2017, volume: 30, edition: 6, DOI
2016
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Apocynin and Diphenyleneiodonium Induce Oxidative Stress and Modulate PI3K/Akt and MAPK/Erk Activity in Mouse Embryonic Stem Cells
Oxidative Medicine and Cellular Longevity, year: 2016, volume: 2016, edition: 7409196, DOI
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CASEIN KINASE 1 INHIBITORS FOR THE TREATMENT OF B-CELL CHRONIC LYMPHOCYTIC LEUKEMIA
Publisher: Canadian Intellectual Property Office, state: Canada, patent's number: CA 2876908, year: 2016
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CASEIN KINASE 1 INHIBITORS FOR THE TREATMENT OF B-CELL CHRONIC LYMPHOCYTIC LEUKEMIA
Publisher: European patent Office, state: Germany, patent's number: EP2882437 (B1), year: 2016
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Stage-specific roles of FGF2 signaling in human neural development
Stem Cell Research, year: 2016, volume: 17, edition: 2, DOI
2015
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Alkaline phosphatase in stem cells
Stem Cells International, year: 2015, volume: 2015, edition: 02, DOI
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Asymmetry of VANGL2 in migrating lymphocytes as a tool to monitor activity of the mammalian WNT/planar cell polarity pathway
Journal of Cell Communication and Signaling, year: 2015, volume: 13, edition: January, DOI
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NOD/SCID IL2R gamma-null mouse xenograft model of human p53-mutated chronic lymphocytic leukemia and ATM-mutated mantle cell lymphoma using permanent cell lines
Leukemia & Lymphoma, year: 2015, volume: 56, edition: 11, DOI
2014
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beta-Arrestin Interacts with the Beta/Gamma Subunits of Trimeric G-Proteins and Dishevelled in the Wnt/Ca2+ Pathway in Xenopus Gastrulation
PLOS ONE, year: 2014, volume: 9, edition: 1, DOI
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beta-Arrestin Promotes Wnt-induced Low Density Lipoprotein Receptor-related Protein 6 (Lrp6) Phosphorylation via Increased Membrane Recruitment of Amer1 Protein
Journal of Biological Chemistry, year: 2014, volume: 289, edition: 2, DOI