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Project information
Elektrostaticky zvlákněná biodegradabilní nanovlákna pokrytá plazmově připravenými aminovými vrstvami pro využití v biomedicíně

Project Identification
LD15150
Project Period
10/2015 - 5/2017
Investor / Pogramme / Project type
Ministry of Education, Youth and Sports of the CR
  • COST CZ
MU Faculty or unit
Central European Institute of Technology

The aim of this project is to deposit stable amine-rich coatings onto a biodegradable nanofibrous material and to prove its increased bioactivity. This proposal coincides with the COST Action MP1206, namely the topic of the working group 3, “Biomedical applications of electrospun nanofibrous materials”. The proposed research will contribute to the promotion of nanofibers for the biomedical use. The particular objectives of the project are:

  • Find electrospinning conditions suitable for the preparation of biodegradable nanofibrous mesh with the fiber thickness ~500-1500 nm and the pore size ~5-15 μm.
  • Find the conditions of low pressure plasma polymerization of cyclopropylamine and plasma pre-treatment conditions suitable for uniform coating of nanofibers with amine-rich layers.
  • Correlate plasma pre-treatment and deposition conditions with the coating chemical structure, adhesion to polymer nanofibers, aging and stability of amine-layers in water.
  • Conclude on an enhancement of cell adhesion and proliferation on the amine-coated nanofibrous material compared to the untreated surfaces.
  • Determine the exent of an antigen or antibody attachment to the nanofibrous mesh and evaluate a prospectiveness of the application for a controlled vaccination or ant-viral/anti-microbe treatment.

Publications

Total number of publications: 5

2018

2017

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