Project information
Molecular pathophysiology of multigene diseases
- Project Identification
- MSM 141100002
- Project Period
- 1/1999 - 1/2004
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Faculty of Medicine
- Keywords
- Multigenic disease, essential hypertension, ischemia, atopy, diabetes type II, late complications of diabetes, matrix metalloproteinase, gene polymorphism, remodeling, gene derepression, case-control study, PCR, SSCP, RFLP, sequencing.
Effects of allelic variability of the genes coding for matrix metalloproteinases (MMPs) on the etiopathogenesis of the essential hypertension, myocardial ischemia, atopic diseases, and late complications of diabetes II will be studied. Genotyping of individuals will be performed using molecular biological methods, especially PCR, SSCP, RFLP, and/or direct sequencing. Groups of diseased persons will be compared with the appropriate control groups (case-control study).
Publications
Total number of publications: 232
2010
2009
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MATRIX METALLOPROTEINASE -2 GENE VARIABILITY IN PSORIASIS
6th EADV Spring Symposium on Psoriasis, year: 2009
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RELATIONS BETWEEN THREE POLYMORPHISMS IN HLA RELATED GENES AND HEREDITY IN PSORIASIS PATIENTS
6th EADV Spring Symposium on Psoriasis, year: 2009
2008
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Adaptive photo-thermal anticipation controls boundaries and population volume
In preparation, year: 2008
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No association of defined variability in leptin, leptin receptor, adiponectin, proopiomelanocortin and ghrelin gene with food preferences in the Czech population
Nutritional Neuroscience, year: 2008, volume: 2008, edition: 11
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Srdeční selhání u žen
Postgraduální medicína, year: 2008, volume: 10, edition: suppl.1
2007
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Are common leptin promoter polymorphisms associated with restenosis after coronary stenting?
Heart Vessels, year: 2007, volume: 2007, edition: 22(5)
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Dynamics of nuclear transcription autoregulation: Bifurcation and periodic solutions in a negative feedback loop with delay
Physica D - Nonlinear Phenomena, year: 2007, volume: 2010, edition: revised
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Genetic risk factors for diabetic nephropathy on chromosomes 6p and 7q identified by the set-association approach
Diabetologia, year: 2007, volume: 50, edition: 5
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HFE C282Y gene variant is a risk factor for the progression to decompensated liver disease in chronic viral hepatitis C subjects in Czech population
Hepatology Research, year: 2007, volume: 37, edition: 9