Project information
Efekt diabetického mikroprostředí na vybrané procesy při vzniku kolorektálního karcinomu, jeho klinický průběh a odpověď na terapii
- Project Identification
- GA16-14829S
- Project Period
- 1/2016 - 12/2018
- Investor / Pogramme / Project type
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Czech Science Foundation
- Standard Projects
- MU Faculty or unit
- Faculty of Medicine
- Cooperating Organization
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Masaryk Memorial Cancer Institute Brno
- Responsible person prof. MUDr. Kateřina Kaňková, Ph.D.
Projekt si klade za cíl studovat vztah mezi glukotoxicitou indukovanou diabetem, aktivitou p53 a efektem metforminu na biologické vlastnosti kolorektálního karcinomu
Publications
Total number of publications: 9
2019
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AGR2 silencing contributes to metformin-dependent sensitization of colorectal cancer cells to chemotherapy
Oncology letters, year: 2019, volume: 18, edition: 5, DOI
2018
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Deleterious Effect of Advanced CKD on Glyoxalase System Activity not Limited to Diabetes Aetiology
International Journal of Molecular Sciences, year: 2018, volume: 19, edition: 5, DOI
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Hyperglykemie, 5-fluorouracil, a delece p53 ovlivňují proteinovou hladinu GLO1 u buněčné linie HCT116 a Dld1
Year: 2018, type: Conference abstract
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Pathophysiological link between diabetes and colorectal cancer: effect of diabetic microenvironment, metformin and 5-fluorouracil on glyoxalase 1 protein level
Year: 2018, type: Conference abstract
2017
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Levels of heavy metals and their binding protein metallothionein in type 2 diabetics with kidney disease
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, year: 2017, volume: 31, edition: 6, DOI
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Pathophysiological link between diabetes and colorectal cancer: effect of diabetic microenvironment, metformin and 5-fluorouracil on AMPK activation, apoptosis and autophagy
Year: 2017, type: Conference abstract
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The effect of type 2 diabetes on selected clinical parameters and disease outcome in patients with colorectal cancer
Year: 2017, type: Conference abstract
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Vliv diabetického mikroprostředí na vznik a rozvoj nádorů
Year: 2017, type: Conference abstract
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Vliv diabetického mikroprostředí, metforminu a 5-fluorouracilu na aktivaci AMPK v buňkách kolorektálního karcinomu in vitro
Year: 2017, type: Conference abstract