Project information
CZ-OPENSCREEN: National Infrastructure for Chemical Biology
(CZ-OPENSCREEN)
- Project Identification
- LM2015063
- Project Period
- 1/2016 - 12/2019
- Investor / Pogramme / Project type
-
Ministry of Education, Youth and Sports of the CR
- Large Infrastructures for Research, Development and Innovation
- MU Faculty or unit
- Faculty of Science
- Cooperating Organization
-
Institute of Molecular Genetics of the ASCR, v. v. i.
- Responsible person RNDr. Petr Bartůněk, CSc.
Prague Institute of Chemical Technology
The aim of the project „CZ-‐OPENSCREEN: National infrastructure for chemical
biology” is to operate the state-‐of-‐the-‐art infrastructure for basic and applied
research in the fields of chemical biology and genetics and provide Open Access to users. It will serve as the National node of the pan-European ESFRI infrastructure EU-‐OPENSCREEN, providing trans-‐national access to the
Screening platform and to the European Chemical Biology Library. The mission
of CZ-‐OPENSREEN is to identify new molecular probes/tools for research and
new potential therapeutics.
Publications
Total number of publications: 31
2022
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백혈병, 림프종 및 고형 종양의 치료에 사용하기 위한 4-(1H-이미다졸-5-일)-1H-피롤로[2,3-b]피리딘
Publisher: Korean Intellectual Property Office, state: Korea, Republic of, patent's number: KR10-2465111, year: 2022
2021
-
Stereocontrolled Synthesis of Pseurotin A(2)
Journal of Organic Chemistry, year: 2021, volume: 86, edition: 17, DOI
2020
-
Cdc-Like Kinases (CLKs): Biology, Chemical Probes, and Therapeutic Potential
International Journal of Molecular Sciences, year: 2020, volume: 21, edition: 20, DOI
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Conformational Control of the Photodynamics of a Bilirubin Dipyrrinone Subunit: Femtosecond Spectroscopy Combined with Nonadiabatic Simulations
Journal of Physical Chemistry, year: 2020, volume: 124, edition: 50, DOI
-
Furopyridines as inhibitors of protein kinases
Publisher: European Patent Office, state: Germany, patent's number: EP2940022, year: 2020
-
Natural pseurotins and analogs thereof inhibit activation of B-cells and differentiation into the plasma cells
Phytomedicine, year: 2020, volume: 69, edition: APR 2020, DOI
-
Stereocontrolled Synthesis of (-)-Bactobolin A
Journal of the American Chemical Society, year: 2020, volume: 142, edition: 16, DOI
-
Substituted propanamides as inhibitors of nucleases
Publisher: European Patent Office, state: Germany, patent's number: EP3556756, year: 2020
-
The CHK1 inhibitor MU380 significantly increases the sensitivity of human docetaxel-resistant prostate cancer cells to gemcitabine through the induction of mitotic catastrophe
Molecular oncology, year: 2020, volume: 14, edition: 10, DOI
-
Wavelength-Dependent Photochemistry and Biological Relevance of a Bilirubin Dipyrrinone Subunit
Journal of Organic Chemistry, year: 2020, volume: 85, edition: 20, DOI