Project information
Plant sources of minor benzofenantridine alkaloids and study of heir interaction with DNA
- Project Identification
- GA525/08/0819
- Project Period
- 3/2008 - 12/2010
- Investor / Pogramme / Project type
-
Czech Science Foundation
- Standard Projects
- MU Faculty or unit
- Faculty of Medicine
- Keywords
- benzofenantridine alkaloids,DNA,Stylophorum
Benzo[c]phenathridine alkaloids display many significant biological effects and are very intensively studied during pastr years. In addition to long time known sanquinarine and chelerythrine also the minor benzo[c]phenanhtidines sanquilutine, chelilutine, chelirubine, sanquirubine a macarpine are discussed.
Publications
Total number of publications: 19
2012
-
Investigation of sanguinarine and chelerythrine effects on LPS-induced inflammatory gene expression in THP-1 cell line
Phytomedicine, year: 2012, volume: 19, edition: 10, DOI
-
Isolation of Quaternary Benzo[c] phenanthridine Alkaloids from Macleaya microcarpa (MAXIM.) FEDDE: Comparison of Maceration, Soxhlet Extraction and Pressurised Liquid Extraction
Phytochemical Analysis, year: 2012, volume: 23, edition: 5, DOI
-
Necroptosis modulated by autophagy is a predominant form of melanoma cell death induced by sanguilutine
Biological Chemistry, year: 2012, volume: 393, edition: 7, DOI
2011
-
Benzo[c]phenanthridine alkaloids exhibit strong anti-proliferative activity in malignant melanoma cells regardless of their p53 status
Journal of Dermatological Science, year: 2011, volume: 62, edition: 1, DOI
-
Seasonal Variation of Bioactive Alkaloid Contents in Macleaya microcarpa (Maxim.) Fedde
Molecules, year: 2011, volume: 16, edition: 4, DOI
2010
-
Algicidal and cyanocidal effects of selected isoquinoline alkaloids
Aquaculture Research, year: 2010, volume: 41, edition: 4
-
Effect of quaternary benzo[c]phenanthridine alkaloids sanguilutine and chelilutine on normal and cancer cells
Toxicology in Vitro, year: 2010, volume: 24, edition: 3
-
Extractions of isoquinoline alkaloids with butanol and octanol
Fitoterapia, year: 2010, volume: 81, edition: 6
-
Phytochemical and antimicrobial characterization of Macleaya cordata herb
Fitoterapia, year: 2010, volume: 81, edition: 8
-
Quaternary Benzo(c) Phenantridine Alkaloids: Perspective Flourescence DNA Probes
Alkaloids: Properties, Applications and Pharmacological Effects, year: 2010, number of pages: 19 s.