Project information
Visible light-activated photocaged molecules for biological applications
(VLAMBA)
- Project Identification
- 6SA17811
- Project Period
- 5/2017 - 4/2020
- Investor / Pogramme / Project type
-
South-Moravian Region
- SoMoPro
- Incoming grants
- MU Faculty or unit
-
Faculty of Science
- Mgr. Peter Štacko
- Mgr. Peter Štacko
Using light as the control stimulus in biological settings offers unparalleled advantages in terms of availability, very high spatial and temporal precision, high orthogonality towards biochemical systems and lack of waste products. For therapeutic applications, wavelength of light plays a crucial role as only wavelengths between 600–1200 nm possess the ability to significantly penetrate living tissue. Unfortunately, with just a few examples available, direct photochemical release of molecules with wavelengths in the visible and near-infrared spectrum constitutes a significant challenge in contemporary chemistry. Therefore, the project aims to identify and develop new systems for visible light-induced release and control of biologically relevant functionalities (i.e. alcohols, carboxylic acids) or small molecules (i.e. gasotransmitters) to provide a platform for in vitro and potential in vivo applications. To this end, we seek to utilize well-established and biocompatible chromophores and use computational chemistry for rational design of the candidates. Upon successful demonstration of photochemical release under biologically compatible conditions, the system will be applied in biological and in vitro studies.
Publications
Total number of publications: 4
2020
-
Cyanine-Flavonol Hybrids for Near-Infrared Light-Activated Delivery of Carbon Monoxide
Chemistry - A European Journal, year: 2020, volume: 26, edition: 58, DOI
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Deciphering the Structure-Property Relations in Substituted Heptamethine Cyanines
Journal of Organic Chemistry, year: 2020, volume: 85, edition: 15, DOI
2019
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Approach to a Substituted Heptamethine Cyanine Chain by the Ring Opening of Zincke Salts
Journal of the American Chemical Society, year: 2019, volume: 141, edition: 17, DOI
2018
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Visible to NIR Light Photoactivation of Hydrogen Sulfide for Biological Targeting
Organic Letters, year: 2018, volume: 20, edition: 16, DOI