Project information
Interdisciplinary approach to study biological systems at the molecular level
- Project Identification
- LTC17076
- Project Period
- 5/2017 - 3/2020
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- INTER-EXCELLENCE
- INTER-COST
- MU Faculty or unit
- Central European Institute of Technology
Projekt je zaměřen na integrativní inovační biofyzikální přístupy pro studium proteinů specificky rozpoznávajících sacharidy podílejících se na interakci hostitel-patogen a dále enzymů zapojených do biosyntézy glykokonjugátů. Studované téma je v souladu s akcí COST CA15126 zaměřením na vývoj nových metodologií a technologií, které mají pomoci posunout existující biofyzikální instrumentaci novými nejmodernějšími směry.
Sustainable Development Goals
Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.
Publications
Total number of publications: 11
2020
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Catalytic Mechanism of Processive GlfT2: Transition Path Sampling Investigation of Substrate Translocation
ACS Omega, year: 2020, volume: 5, edition: 34, DOI
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Characterization of novel lectins from Burkholderia pseudomallei and Chromobacterium violaceum with seven-bladed beta-propeller fold
International journal of biological macromolecules, year: 2020, volume: 152, edition: JUN, DOI
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The CH-pi Interaction in Protein-Carbohydrate Binding: Bioinformatics and In Vitro Quantification
Chemistry - A European Journal, year: 2020, volume: 26, edition: 47, DOI
2019
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Lectin PLL3, a Novel Monomeric Member of the Seven-Bladed beta-Propeller Lectin Family
Molecules, year: 2019, volume: 24, edition: 24, DOI
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Synthesis of beta-D-galactopyranoside-Presenting Glycoclusters, Investigation of Their Interactions with Pseudomonas aeruginosa Lectin A (PA-IL) and Evaluation of Their Anti-Adhesion Potential
Biomolecules, year: 2019, volume: 9, edition: 11, DOI
2018
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AB21, a protein of unknown function from Agaricus bisporus. A case study on utilizing experimental and bioinformatical approaches for functional assignment of unknown proteins
Year: 2018, type: Conference abstract
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Assessing the Performance of MM/PBSA, MM/GBSA, and QM-MM/GBSA Approaches on Protein/Carbohydrate Complexes: Effect of Implicit Solvent Models, QM Methods, and Entropic Contributions
Journal of Physical Chemistry B, year: 2018, volume: 122, edition: 34, DOI
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Automated Training of ReaxFF Reactive Force Fields for Energetics of Enzymatic Reactions
Journal of Chemical Theory and Computation, year: 2018, volume: 14, edition: 1, DOI
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How Mycobacterium tuberculosis Galactofuranosyl Transferase2 (GlfT2) Generates Alternating beta-(1-6) and beta-(1-5) Linkages: AQM/MM Molecular Dynamics Study of the Chemical Steps
Chemistry - A European Journal, year: 2018, volume: 24, edition: 27, DOI
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Structure and properties of AB21, a novel Agaricus bisporus protein with structural relation to bacterial pore-forming toxins
Proteins : structure, function, and genetics, year: 2018, volume: 86, edition: 9, DOI