Project information
Alternative mechanisms of deregulation of the p53 pathway in chronic lymphocytic leukemia
- Project Identification
- GA19-15737S (kod CEP: GA19-15737S)
- Project Period
- 1/2019 - 6/2022
- Investor / Pogramme / Project type
-
Czech Science Foundation
- Standard Projects
- MU Faculty or unit
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Central European Institute of Technology
- prof. RNDr. Šárka Pospíšilová, Ph.D.
- Mgr. Veronika Mančíková, Ph.D.
- Cooperating Organization
-
University Hospital Brno-Bohunice
Eventually almost all cancers escape the tumor suppression control by the key genome guardian p53, most frequently by genetic mutations but also by other mechanisms. Defects in p53 are widely accepted to be the most significant marker of poor prognosis among chronic lymphocytic leukemia (CLL) patients. We hypothesize that apart from a direct genetic impairment, other mechanisms acting upon p53 protein could be driving CLL. Therefore, we plan to portray the landscape of phosphorylation modifications of p53 in primary human CLL cells treated with a clinically relevant drug set. We anticipate to identify differences among patients with distinct genetic background and with diverse clinical outcome.
Publications
Total number of publications: 15
2023
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Distinct p53 phosphorylation patterns in chronic lymphocytic leukemia patients are reflected in the activation of circumjacent pathways upon DNA damage
MOLECULAR ONCOLOGY, year: 2023, volume: 17, edition: 1, DOI
2022
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Distinct p53 phosphorylation patterns in chronic lymphocytic leukemia patients are reflected in circumjacent pathways activation upon DNA damage
Year: 2022, type: Conference abstract
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Distinct p53 phospohrylation patterns in chronic lymphocytic leukemia patients are reflected in circumjacent pathways activation upon DNA damage.
Year: 2022, type: Conference abstract
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Evolution of TP53 abnormalities during CLL disease course is associated with telomere length changes
BMC Cancer, year: 2022, volume: 22, edition: 1, DOI
2021
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Comparative analysis of targeted next-generation sequencing panels for the detection of gene mutations in chronic lymphocytic leukemia: an ERIC multi-center study
haematologica, year: 2021, volume: 106, edition: 3, DOI
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Fosforylace proteinu p53: vliv na aktivitu dráhy p53 po poškození DNA u chronické lymfocytární leukémie.
Year: 2021, type: Conference abstract
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Identification and functional characterization of new missense SNPs in the coding region of the TP53 gene
Cell Death and Differentiation, year: 2021, volume: 28, edition: 5, DOI
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Klinický dopad a evoluce minoritních TP53-mutovaných klonů v kontextu různých terapeutických režimů u CLL.
Year: 2021, type: Conference abstract
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Low-burden TP53 mutations in CLL: clinical impact and clonal evolution within the context of different treatment options
Blood, year: 2021, volume: 138, edition: 25, DOI
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STAT3 and TP53 mutations associate with poor prognosis in anaplastic large cell lymphoma
Leukemia, year: 2021, volume: 35, edition: 5, DOI