Project information
Czech Infrastructure for Integrative Structural Biology
(CIISB)
- Project Identification
- LM2018127
- Project Period
- 1/2020 - 12/2022
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Large Infrastructures for Research, Development and Innovation
- MU Faculty or unit
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Central European Institute of Technology
- prof. RNDr. Vladimír Sklenář, DrSc.
- Cooperating Organization
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Institute of Biotechnology CAS
The Czech Infrastructure for Integrative Structural Biology (CIISB) is a distributed infrastructure of the core facilities and central laboratories of CEITEC (Central European Institute of Technology, Brno) and BIOCEV (Biotechnology and Biomedicine Centre, Vestec) providing expertise and access to technologies used for integrative approaches to structural analysis of biologically important cellular components and macromolecules - proteins, nucleic acids, and their complexes. CIISB, equipped with the cutting-edge technologies, will offer access to the equipment and expertise in the following fields: high-field NMR spectroscopy; high throughput crystallization of biological macromolecules; X-ray diffraction techniques; Bio-SAXS measurements; AFM imaging; characterization of proteins, nucleic acids and complexes by biophysical methods including microcalorimetry, dynamic light scattering, and surface plasmon resonance; high-end cryo-electron microscopy and tomography allowing studies of cellular structures, organelles, and biomacromolecular complexes by 3D imaging; protein expression in eukaryotic cells; high-end mass spectrometry characterization of biomacromolecules; determination of protein post-translational modifications; MS-based peptide mapping/sequencing; high throughput sequencing and proteomic services. CIISB infrastructure aims to provide a high quality open access services in provision of methods and techniques on a level of national and trans-national importance. CIISB is a part of the ESFRI project INSTRUCT-ERIC.
Sustainable Development Goals
Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.
Publications
Total number of publications: 327
2022
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From nano- to milimolar: dimerization dissociation constant determination
Year: 2022, type: Conference abstract
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Geometric Control of Cell Behavior by Biomolecule Nanodistribution
ACS BIOMATERIALS SCIENCE & ENGINEERING, year: 2022, volume: 8, edition: 11, DOI
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Hands-on-Session: Bruker MultiMode 8HR
Year: 2022, type: Workshop
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hESC derived cardiomyocyte biosensor to detect the different types of arrhythmogenic properties of drugs
Analytica Chimica Acta, year: 2022, volume: 1216, edition: July 2022, DOI
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Highly Efficient and Selective Recognition of Dicyanoaurate(I) by a Bambusuril Macrocycle in Water
Angewandte Chemie International Edition, year: 2022, volume: 61, edition: 43, DOI
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Histone Variant macroH2A1.1 Enhances Nonhomologous End Joining-dependent DNA Double-strand-break Repair and Reprogramming Efficiency of Human iPSCs
Stem Cells, year: 2022, volume: 40, edition: 1, DOI
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Human myelin proteolipid protein structure and lipid bilayer stacking
Cellular and molecular life sciences, year: 2022, volume: 79, edition: 8, DOI
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Characterisation of Waterborne Psychrophilic Massilia Isolates with Violacein Production and Description of Massilia antarctica sp. nov.
Microorganisms, year: 2022, volume: 10, edition: 4, DOI
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Characterization of insulin crystalline form in isolated beta-cell secretory granules
Open Biology, year: 2022, volume: 12, edition: 12, DOI
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Characterization of the AGR2 Interactome Uncovers New Players of Protein Disulfide Isomerase Network in Cancer Cells
Molecular & Cellular Proteomics, year: 2022, volume: 21, edition: 2, DOI