Project information
Investigation of mechanical forces generated by mammary fibroblasts and their role in mammary epithelial morphogenesis

Mechanical forces are ubiquitous and integral part of tissue morphogenesis and homeostasis. Through mechanosignaling, they regulate cell behavior and fate, while aberrations in mechanosignaling lead to developmental defects and cancer. Our understanding of mechanical forces in mammary development is very incomplete. In this project, I will investigate the mechanical forces of mammary fibroblasts and their roles in mammary epithelial morphogenesis using traction force and genetic mouse models.